Creative Biolabs, a leader in innovative bio-scientific solutions, is proud to offer comprehensive solutions tailored to meet the intricate needs of therapeutic antibody and protein development projects. Among our array of specialized services, our 5-HT receptor panel screening service has been developed to measure both agonist and antagonist activities in therapeutic compounds.

5-HT Receptors

5-HT receptors, or serotonin receptors, are a class of G protein-coupled receptors (GPCRs) present in both the central and peripheral nervous systems. They are activated by serotonin, a neurotransmitter that plays a crucial role in regulating physiological and cognitive processes, such as mood, appetite, and memory. Due to their widespread influence on human health, 5-HT receptors have become crucial targets for drug development in neurological and psychiatric disorders. There are seven major classes of 5-HT receptors, each with unique structural and functional characteristics, making them a complex yet fascinating target for therapeutic exploration.

Fig.1 Structure of 5-HT receptors.¹

Our Comprehensive 5-HT Receptor Panel Screening Service

Recognizing the need for precise and reliable assays in therapeutic discovery, Creative Biolabs has developed an innovative 5-HT receptor panel screening service. This service is designed to facilitate the measurement of agonist or antagonist activity across various 5-HT receptor subtypes, providing invaluable insights into receptor-ligand interactions. Our service is supported by a robust platform of overexpression-stable cell lines engineered specifically for each 5-HT receptor subtype. These cell lines ensure the consistency and reliability of results, enabling researchers to make informed decisions throughout the drug development process.

Our 5-HT receptor panel encompasses a comprehensive array of receptor subtypes including, but not limited to, 5-HT1A, 5-HT2A, 5-HT2B, and 5-HT4. This extensive coverage ensures that the diverse functionalities and potential off-target interactions of your therapeutic candidates are thoroughly assessed.

Service Highlights

• Diverse Receptor Coverage: Our panel covers a broad range of 5-HT receptors, ensuring comprehensive analysis and exceptional insight into potential therapeutic effects and side effects.
• Advanced Functional Assays: Our advanced assays go beyond traditional receptor-ligand binding. They offer an in-depth exploration of functional outcomes, providing critical data on both agonistic and antagonistic interactions.
• Experienced Scientific Team: Our team comprises experts with extensive experience in receptor biology and pharmacology. We support every client with personalized service, addressing unique project needs and expectations.
• Compliance with Industry Standards: All services strictly adhere to current regulatory guidelines, ensuring your therapeutic development project maintains the highest industry standards for quality, reliability, and safety.

Applications

• Neuropsychiatric Drug Development
  Our 5-HT receptor panel enables precise evaluation of compound activity across serotonin receptor subtypes, supporting the development of drugs for depression, anxiety, and other neuropsychiatric disorders.
• Agonist/Antagonist Profiling
  The service facilitates detailed profiling of therapeutic antibodies or proteins as agonists or antagonists, offering critical insights into receptor-ligand interactions for targeted therapeutic design.
• Off-Target Risk Assessment
  By screening against multiple 5-HT receptor subtypes, potential off-target effects can be identified early, improving compound safety and guiding lead optimization.
• Structure-Activity Relationship (SAR) Studies
  Comprehensive 5-HT subtype coverage supports SAR studies by revealing how structural changes affect receptor binding and functional activity, accelerating candidate refinement.

Whether you are targeting neuropsychiatric disorders or exploring new therapeutic pathways, our expert team at Creative Biolabs is ready to support your journey from discovery to market. Contact us to learn more about how our 5-HT receptor panel screening services can be tailored to meet your specific research needs.

Reference

1. Imamdin, Aqeela, and Emiel PC van der Vorst. "Exploring the role of serotonin as an immune modulatory component in cardiovascular diseases." International Journal of Molecular Sciences 24.2 (2023): 1549. under Open Access license CC BY 4.0, without modification.

For Research Use Only | Not For Clinical Use