Bacterial Composition & Tumor Gene Expression Correlation Analysis Service
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Are you currently facing challenges on profiling microbial composition, dissecting their pivotal roles, and charting new translational avenues for microbiome-driven cancer therapeutics? Creative Biolabs' bacterial compositions and tumor gene expression correlation analysis service helps you unlock the hidden links between the microbiome and host genetics through advanced sequencing methods and integrated analysis. We deliver comprehensive bacterial-composition profiling coupled with high-resolution correlation analyses against tumor-cell keys genes, empowering you to uncover novel therapeutic targets and accelerate translational momentum.
Introduction
The bacteria within cancer cells act as master epigenetic and transcriptional regulators. They can directly influence the expression of critical genes and hijack key pathways such as WNT, NF-κB and Rho-GTPase pathways, promoting oncogenesis, facilitating metastasis, and modulating chemoresistance. Understanding the correlation between bacteria and key genes expression in tumor cells offers new insights into cancer development and potential therapeutic targets.
Fig.1 Mechanisms underlying bacterial invasion of tumor cells.1
Bacterial Compositions and Tumor Gene Expression Correlation Analysis Service at Creative Biolabs
Creative Biolabs' bacterial compositions and tumor gene expression correlation analysis service is designed to move beyond simple association by uncovering the direct, functional interplay between microbial communities and host cellular processes. Our analyses do well in revealing how a specific microbial metabolite may "switch" the function of a key cancer gene or how a distinct bacterial community in a tumor can predict the response of a patient to neoadjuvant therapy. Through these analyses, we deliver a powerful solution for identifying new diagnostic markers, prognostic indicators, and therapeutic targets.
What We Can Offer?
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We offer a comprehensive portfolio of sequencing strategies tailored to your research objectives, including 16S rRNA gene sequencing, metagenomics, long-read platforms and so on.
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We adhere to rigorous quality-control and data-processing protocols. Firstly, we performed meticulous background-noise filtration, and then we proceed to precise taxonomic annotation. Finally, we conducted comprehensive functional characterization.
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We deploy a suite of integrative association strategies, such as microbe–gene Pearson correlation, multivariate association modeling, co-expression network construction, and survival linkage analyses, in order to dissect the interplay between microbial signatures and tumor biology across multiple dimensions including key gene expression profiles, pathway activation states, and patient survival outcomes.
Our Service Process
To initiate this project, the following materials are required:
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Fresh-frozen or FFPE tissue biopsies
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Liquid biopsy samples
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Existing clinical data such as patient demographics, treatment history and survival data
Key steps:
Final deliverables:
You will receive a comprehensive report summarizing all findings, a list of candidate microbial biomarkers, and a table of correlated host genes and pathways.
Key Advantages
Leveraging our deep expertise and robust technology platforms, Creative Biolabs is uniquely positioned to address your most complex research challenges.
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Customized Project Design: We meticulously tailor each project to address your unique research questions, whether you are investigating a specific disease model, exploring a novel therapeutic intervention, or conducting a broad pan-cancer study.
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Cutting-Edge Bioinformatics: We employ advanced tools to identify direct and biologically significant correlations, moving beyond simple associations to provide mechanistic insight.
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Expert Data Interpretation: We have experienced microbiologists, geneticists, and bioinformaticians. They will provide expert analysis, translating complex data into clear, actionable findings and strategic recommendations.
FAQs
Q1: What sample types are suitable for this service?
A1: We can analyze a broad spectrum of sample types, including fresh-frozen and formalin-fixed paraffin-embedded (FFPE) tumor tissues, as well as liquid biopsies.
Q2: What is difference between your approach and other standard microbiome sequencing services?
A2: Compared with other standard services, we provide not only a list of bacteria, but also an integrated analysis with host gene expression data from the same sample. This dual-omics approach is useful for us to identify direct and functional correlations, giving you a deeper and more actionable understanding of the biological mechanisms.
Q3: What if I already have my own sequencing data?
A3: Our bioinformatics team specializes in re-analyzing and consolidating diverse datasets to maximize their analytical potential. We will harness your existing data and integrate it seamlessly across multiple sequencing platforms.
Why Choose Us?
Creative Biolabs excels through the integration of biological acumen and advanced computational capabilities. Our bacterial compositions and tumor gene expression correlation analysis service has extensive experience in interpreting complex data, aiming at identifying robust microbial biomarkers and mechanistic links.
Customer Reviews
" The analysis from Creative Biolabs was a huge change for our research. Their service clarified how a specific gut metabolite could 'switch' our mutant p53 from a tumor suppressor to an oncogene, providing a molecular-level explanation that was previously a black box. " - Dr. A***n H.
" Using Creative Biolabs' service, we were able to pinpoint the exact mechanism by which H. pylori impact gastric cancer. The correlation with P27 expression provided us with a novel, actionable target for our therapeutic development program. " - Dr. B***a M.
"Our pan-cancer study required a sophisticated approach to handle massive datasets. The advanced analysis provided by Creative Biolabs helped us find non-obvious correlations between the tumor microbiome and gene expression, giving us a significant advantage over standard methods." - Dr. C***s L.
How to Contact Us?
To learn more and to discuss how our services can be tailored to meet your specific research goals, please contact our expert team. We are poised to assist you in elucidating critical biological insights.
Contact us for additional information and to delve into your project.
Reference
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Zhu, Wei et al. "The bacteria inside human cancer cells: Mainly as cancer promoters." Frontiers in oncology vol. 12 897330. 12 Aug. 2022. Distributed under Open Access License CC BY 4.0, without modification. DOI: https://doi.org/10.3389/fonc.2022.897330
