Point Mutation Cell Line Products

Point mutation cell lines refer to cell lines that have been genetically engineered to contain specific point mutations, which are alterations at a single nucleotide in the DNA sequence. These modified cell lines are valuable tools for researchers studying gene function, signaling pathways, and drug responses, as they can mimic particular genetic abnormalities or disease conditions. They provide a controlled environment for investigating the effects of mutations on cellular behavior and are particularly useful in cancer and genetic disease studies, aiding in the understanding of disease mechanisms and potential therapeutic targets.

Advantages of Point Mutation Cell Lines

Disease Modeling

Point mutations are frequently linked to a number of illnesses, including cancer.

Drug Development

The effectiveness of novel medications can be evaluated using point mutation cell lines.

Targeted Therapy Research

Targeted treatments could be developed as a result of point mutations.

Functional Studies

You can investigate the functional consequences of individual mutations in a controlled environment.

High-throughput Screening

These cell lines can be utilized in high-throughput screening assays to quickly evaluate the effects of thousands of compounds on cells with specific mutations, facilitating rapid drug discovery.

Featured Products

Cat. NO	Product Name	Mutant Gene	Applications
ITS-0624-HMM40	CellOnco™ CHO-K1-Tg(Human GPBA Receptor W83G) Stable Cell Line, Single Clone	W83G	Immunotherapy Research
ITS-0624-HMM41	CellOnco™ CHO-K1-Tg(Human GPBA Receptor W83A) Stable Cell Line, Single Clone	W83A	Immunotherapy Research

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Applications of Point Mutation Cell Lines

Cancer Research
The development of cancer is often linked to point mutations. Cell lines that harbor specific point mutations allow you to study the mechanisms of cancer progression, the effects of mutations on cell behavior, and the molecular pathways involved.
Drug Development and Screening
Mutant cell lines can be used to test the efficacy of new drugs. For example, you can create cell lines with specific mutations that confer resistance to certain therapies, allowing them to screen for new compounds that can overcome this resistance.
Functional Genomics
Point mutation cell lines help in understanding gene function and the impact of specific mutations on protein activity. By analyzing how these mutations alter cellular processes, you can gather insights into gene regulation and expression.
Modeling Genetic Diseases
You can develop cell lines that replicate human genetic diseases caused by point mutations. This is particularly useful when studying diseases like cystic fibrosis, muscular dystrophy, and sickle cell anemia.
Biomarker Discovery
Mutant cell lines can be employed to identify biomarkers associated with particular diseases. By comparing the molecular signatures of wild-type and mutant cell lines, you can elucidate potential biomarkers for disease diagnosis or prognosis.
Therapeutic Target Validation
You can create point mutation cell lines to validate potential therapeutic targets by assessing the effects of inhibiting specific mutated proteins on cell survival and proliferation.

Target

GPBA

Workflow of Point Mutation Cell Lines

Published Data

Fig.1 Point mutation. (Inui, et al., 2014) Fig.1 The figure above shows the sequence or location of the gRNA and the specific case of point mutation.¹

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Reference

Inui, Masafumi et al. "Rapid generation of mouse models with defined point mutations by the CRISPR/Cas9 system." Scientific reports vol. 4 5396. Distributed under Open Access license CC BY 4.0, without modification.