Short Description
Measures BBB permeability using a colorimetric method.
Development Stage
Research-Grade Cell-Based Assay Development
Description
This CelluTest™ Parallel Artificial Membrane Permeability Assay-BBB Kit provides a high-throughput model for predicting passive transport across neural membranes. By utilizing a specialized lipid-impregnated filter to simulate the biological interface, the system measures the effective permeability of diverse compounds. This robust analytical tool enables researchers to evaluate compound distribution and neuro-pharmacokinetic properties, facilitating fundamental studies into membrane transport and barrier function.
Features
Features a standardized artificial membrane system for predicting passive blood-brain barrier permeability, providing a high-throughput, non-cell-based screening tool for early-stage pharmacological and central nervous system research.
Process Relevance
Predicting compound permeability to assess transport efficiency and optimize candidate selection in early-stage research.
Application Stage
Lead optimization, ADME profiling, and drug discovery.
Applications
Predict passive permeability of drug candidates across the blood-brain barrier using artificial membrane models in pharmacological studies.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Sample Type
Small molecule compounds in buffer or DMSO.
Research Areas
Pharmacokinetics; Drug Discovery; Neurobiology
Datasheet