CelluTest™ Parallel Artificial Membrane Permeability Assay-BBB Kit

CAT#: ITS-1125-YL47
Product Type: Assay Kit
Species: All Species
Short Description
Measures BBB permeability using a colorimetric method.
Brand
CelluTest
Development Stage
Research-Grade Cell-Based Assay Development
Description
This CelluTest™ Parallel Artificial Membrane Permeability Assay-BBB Kit provides a high-throughput model for predicting passive transport across neural membranes. By utilizing a specialized lipid-impregnated filter to simulate the biological interface, the system measures the effective permeability of diverse compounds. This robust analytical tool enables researchers to evaluate compound distribution and neuro-pharmacokinetic properties, facilitating fundamental studies into membrane transport and barrier function.
Features
Features a standardized artificial membrane system for predicting passive blood-brain barrier permeability, providing a high-throughput, non-cell-based screening tool for early-stage pharmacological and central nervous system research.
Process Relevance
Predicting compound permeability to assess transport efficiency and optimize candidate selection in early-stage research.
Application Stage
Lead optimization, ADME profiling, and drug discovery.
Applications
Predict passive permeability of drug candidates across the blood-brain barrier using artificial membrane models in pharmacological studies.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
PAMPA
Sample Type
Small molecule compounds in buffer or DMSO.
Research Areas
Pharmacokinetics; Drug Discovery; Neurobiology
Size
96 tests
Data Output Type
Permeability coefficient
Assay Time
Assay takes 20 hr, hands-on time 1 hr
Species
All Species
Storage
Store at -20 °C upon receipt to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. During use, minimize the time components are exposed to room temperature and return them promptly to -20 °C storage after handling. Do not store at elevated temperatures for extended periods.
Expiry Date
12 months under recommended storage conditions to ensure optimal performance.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped at room temperature.
Background
The Blood-Brain Barrier (BBB) is a highly selective semipermeable membrane that regulates the transport of molecules into the central nervous system. Assessing the passive permeability of experimental compounds across this barrier is a critical step in neuropharmacology research.
For Research Use Only | Not For Clinical Use
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