GPC3 Assay Portfolio Service
Introduction What We Can Offer Workflow Why Creative Biolabs Customer Reviews FAQs Related Services Contact Us
To speed up the development of GPC3-targeted therapies, Creative Biolabs is dedicated to providing a one-stop GPC3 assay portfolio service to help our clients meet the program requirements. Equipped with state-of-the-art facilities and experienced immune-oncology experts, we can provide services covering the initial target validation in vitro to the later preclinical analysis to meet the requirements of scientific research. Our capabilities extend to identifying novel predictive and prognostic biomarkers, refining treatment strategies, and supporting the entire drug discovery pipeline from target validation to in vivo proof-of-concept studies.
Tumor Target GPC3
GPC3 (Glypican-3, also known as OCI-5, MXR7) is an oncofetal heparan sulfate (HS) glycoprotein that is attached to the cell membrane by glycosylphosphatidylinositol (GPI). GPC3 is expressed widely in embryonic tissues, including the lung, liver, and kidneys, while absent in adult tissues. GPC3 could interact with several receptors and ligands, such as cell adhesion molecules, extracellular matrix components, growth factors, and enzymes. It is reported that GPC3 plays a crucial role in multiple signaling pathways, regulating cell growth and apoptosis in certain cell types.
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Fig.1 Structure of the glypican-3 (GPC3) molecule and involvement in the progression of HCC.1
What We Can Offer
One-Stop Service
We provide a comprehensive, integrated GPC3 assay service, streamlining your project from in vitro target validation to in vivo preclinical analysis and final reporting. This approach eliminates the need for multiple vendors, ensuring faster timelines and simplified communication.
Advanced Platforms & Expertise
With state-of-the-art facilities and a team of experienced immuno-oncology experts, we deliver a portfolio of fast, reliable, and cost-effective GPC3 assay methods. Our expertise in cutting-edge technologies allows us to provide meaningful insights beyond just raw data.
Tailored Solutions
We offer highly customized assay services to align with your specific program requirements. We work closely with you to design bespoke assays for unique research questions, such as analyzing GPC3 isoforms or post-translational modifications. This flexibility ensures you get the exact data you need.
Workflow of EGFR Assay Portfolio Service
Highlights
One-Stop GPC3 Assay Solutions
Our comprehensive suite of GPC3 assay services provides a seamless, integrated solution, combining in vitro (target validation, functional assays) and in vivo (model construction, PK/PD studies) applications to support your entire project lifecycle.
Advanced Platform & Expert-Driven Development
Creative Biolabs ensures the highest quality standards for all GPC3 assays. Our dedicated team of biology experts specializes in efficient upstream and downstream process development, ensuring optimal assay performance and reliable results.
Unwavering Quality Assurance
We operate under a well-established quality system, incorporating quality-by-design principles and employing process analytical techniques (PAT) to guarantee data integrity for critical research and regulatory submissions.
Flexible & Customized Service
Our scalable solutions include pre-validated panels, high-throughput screening, and bespoke assay development to analyze specific GPC3 isoforms or integrate with complex pipelines for therapeutic modalities.
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Customer Reviews
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Accelerated Biomarker Validation
Creative Biolabs' service facilitated our understanding of GPC3's role in HCC progression. Their detailed reports and expert interpretation saved us countless hours, allowing us to focus on downstream therapeutic development rather than assay optimization. - Prof. Ro Js.
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Critical PK/PD Insights
Creative Biolabs' GPC3 service provided invaluable insights into the pharmacokinetics and pharmacodynamics of our GPC3-targeting drug candidates in preclinical models. Their rapid turnaround times meant we could iterate on our drug candidates much faster. - Dr. Ml Pr.
FAQs
What types of samples can I submit for GPC3 analysis?
We accept a wide range of sample types for GPC3 analysis, including formalin-fixed paraffin-embedded tissue blocks, fresh-frozen tissue, and various liquid biopsy samples such as serum, plasma, and other biofluids. Additionally, we can work with isolated DNA/RNA and cultured cell lines or primary cells.
How does Creative Biolabs' GPC3 service aid in the early detection of HCC?
GPC3 has been established as a highly specific and sensitive biomarker for hepatocellular carcinoma (HCC), particularly in early stages where other markers may lack sufficient sensitivity. Our GPC3 assay portfolio service leverages advanced ELISA platforms for quantitative measurement of circulating GPC3 in serum or plasma, offering a non-invasive tool for early detection.
Can your service be customized to analyze specific GPC3 isoforms or post-translational modifications?
Absolutely. While GPC3 is primarily known for its full-length form, various isoforms and post-translational modifications can influence its biological function and diagnostic utility. Our team excels at designing and validating bespoke assays to characterize specific GPC3 isoforms, cleavage products, or modifications relevant to your research.
Related Services
Oncology Biomarker Discovery
Our expertise extends to comprehensive profiling using advanced genomic, proteomic, and metabolomic approaches, enabling the discovery of new targets and pathways that can inform drug development and personalized treatment strategies.
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Antibody Engineering
Custom development and optimization of monoclonal and polyclonal antibodies targeting GPC3 or other cancer-related antigens for research, diagnostic, or therapeutic applications. This includes hybridoma technology, phage display, and antibody humanization.
Learn More →
How to Contact Us
Ready to advance your precision oncology initiatives? Our GPC3 assay portfolio service helps you enhance diagnostic precision, track disease progression, and accelerate biomarker discovery through a comprehensive suite of advanced analytical technologies and expert interpretation.
Contact us for more information and to discuss your project.
Reference
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Nishida, T., and H. Kataoka. "Glypican 3-targeted therapy in hepatocellular carcinoma. Cancers. 2019." Distributed under an Open Access license CC BY 4.0, without modification. DOI: https://doi.org/10.3390/cancers11091339
For Research Use Only | Not For Clinical Use
