PharmaOnco™ HEK293-Tg(Human CTLA4) Stable Cell Line, Single Clone (CAT#: ITS-0822-HMM136)

Creative Biolabs offers HEK293-Tg(Human CTLA4) stable cell line which the CTLA4 gene stably expressed in HEK293 cells.

The HEK293-Tg(Human CTLA4) stable cell line is a genetically modified cell line derived from the HEK293 human embryonic kidney cell line. The cells have been engineered to stably express the human cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene. CTLA4 is a protein receptor that plays a key role in regulating the immune response by inhibiting T cell activation. By introducing the CTLA4 gene into the HEK293 cells, researchers can study the function of this important immune checkpoint protein in a controlled laboratory setting. This stable cell line can be used in various research applications, such as studying the effects of CTLA4 on T cell activation, investigating potential therapeutic targets for autoimmune diseases or cancer, and screening potential drugs that target the CTLA4 pathway.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

CTLA4

Human

HEK293

The CTLA4 gene encodes a protein called cytotoxic T-lymphocyte-associated protein 4, which is a receptor found on the surface of T cells, a type of white blood cell that plays a key role in the immune response. CTLA4 acts as a negative regulator of T cell activation, helping to prevent excessive immune responses that could damage the body's own tissues. Mutations in the CTLA4 gene have been associated with autoimmune diseases, as well as an increased risk of certain types of cancer. Therapies targeting CTLA4, such as checkpoint inhibitors, have been developed to enhance the immune response against cancer cells.