In the field of drug development and discovery, accurately identifying and evaluating potential kinase inhibitors is crucial for therapeutic development, particularly in oncology, immunology, and several chronic conditions. Recognizing the significance of this process, Creative Biolabs offers comprehensive kinase panel services designed to accelerate the identification and optimization of kinase inhibitors.

Comprehensive Kinase Panel Screening

Kinase panels are indispensable tools in drug discovery, providing essential data that informs the selection and optimization of potential inhibitors. These high-throughput screening tools allow researchers to assess the activity of compounds across a variety of kinases simultaneously, saving time and resources. At Creative Biolabs, our kinase panel screening services offer extensive screening capabilities, leveraging a wide array of kinase assays to identify potential inhibitors.

Off-the-shelf Kinase Panels

Creative Biolabs delivers a spectrum of kinase panels, providing detailed insights into the inhibitory activity and specificity of compounds against a broad range of kinases. Here are some of our offerings:

Custom Kinase Panel Development Service

Recognizing that each research or therapeutic project has unique requirements, Creative Biolabs goes beyond predefined panels. We offer custom kinase panel development services, tailored solutions to meet specific research needs. Whether you need a panel focused on a particular subset of kinases, kinases from a specific species, or a combination of wild-type and mutant forms, our expert team will work collaboratively with you to develop and optimize a panel that aligns perfectly with your objectives.

Advanced Assay Technologies

To ensure the highest level of accuracy and reliability, our kinase panels employ state-of-the-art assay technologies, including time-resolved fluorescence resonance energy transfer (FRET) assay and a bioluminescent kinase assay.

• Time-resolved fluorescence FRET assay

This technology combines FRET with time-resolved measurement to provide high sensitivity and low background noise. This makes it an excellent choice for kinase activity assays, where precision and reliability are paramount

• Bioluminescent Kinase Assay

The bioluminescent kinase assay is a luminescent assay that measures kinase activity by quantifying the amount of ADP produced during the reaction. This technology offers a homogeneous, high-throughput compatible method that is suitable for both screening and detailed kinetic studies.

Applications

• Oncology Drug Discovery
  Our kinase panels help identify inhibitors targeting cancer-associated kinases, supporting the development of novel therapies for solid tumors, leukemia, and lymphoma.
• Immunology Research
  Kinase panels facilitate the screening of compounds that modulate immune cell signaling, aiding the development of therapies for autoimmune and inflammatory diseases.
• Chronic Disease Therapeutics
  Screening against diverse kinase targets supports drug development for chronic conditions such as diabetes, neurodegeneration, and cardiovascular disorders.
• Lead Compound Optimization
  Our panels enable comparative analysis of kinase selectivity and potency, accelerating structure-activity relationship studies for lead optimization.
• Custom Target Validation
  Researchers can assess compound effects on specific kinase subsets, including mutant forms, to validate novel drug targets in personalized medicine.

Contact us to learn more about our kinase panel screening service.

For Research Use Only | Not For Clinical Use