Mesenchymal Stem Cell (MSC) Immunophenotyping Service

At Creative Biolabs, our comprehensive mesenchymal stem cell (MSC) immunophenotyping service provides precise characterization using state-of-the-art flow cytometry. This service is built on a critical foundation of verifying specific marker expression. We confirm the presence of standard positive MSC markers (CD105, CD73, and CD90) while meticulously ensuring the absence of key hematopoietic lineage markers (CD45, CD34, CD14, CD11b, CD79a, CD19, and HLA-DR). This rigorous, dual-confirmation approach guarantees the purity and identity of your MSC populations for reliable research and clinical translation.

Introduction to MSC Immunophenotyping

To confidently work with MSCs, you must first be certain of their identity. MSC immunophenotyping provides this certainty. Using flow cytometry, we quantitatively analyze the expression of key surface markers on individual cells. This not only verifies the presence of classic MSC markers and absence of contaminants but also ensures your cell populations are consistent and pure. This level of characterization is vital for reproducible research and is an absolute necessity for developing cell-based therapies that meet regulatory standards, as it allows you to monitor crucial changes that happen as cells are expanded in culture.

Publication

A study used flow cytometry to investigate the heterogeneity of dental pulp mesenchymal stromal cells (DP-MSCs). They found that in their natural state, DP-MSCs are rare and phenotypically diverse, with distinct subpopulations. However, upon in vitro expansion, the cell population changed, with a significant increase in CD56⁺ cells over passages. The study highlights the importance of understanding this cellular heterogeneity for developing standardized and effective cell-based therapies.

Fig.1 Immunophenotypic landscape of human DP-MSCs in vivo.¹

Why Choose Us?

In a field where inconsistent results can halt a project, our MSC immunophenotyping service provides the assurance you need. Whether you are conducting fundamental research, scaling up for preclinical studies, or preparing for a clinical trial, our services provide the essential quality control data required by regulatory bodies. By partnering with Creative Biolabs, you gain more than just a service; you gain a team of experts dedicated to your project's success. We help you establish a foundation of trust, accelerate your research, and enhance product safety and efficacy.

By partnering with Creative Biolabs, you gain more than just a service; you gain a team of experts dedicated to your project's success.

FAQs

Customer Review

• Reliable Purity Assessment
  Using Creative Biolabs' service in our research has significantly improved our ability to confidently assess cell population purity before downstream applications. The detailed reports and rapid turnaround time are invaluable. – Jn*Mn
• Superior Technical Support and Analysis
  We compared several immunophenotyping services and chose Creative Biolabs for their superior technical support and comprehensive gating strategy. Their expertise in excluding debris and dead cells from the analysis gave us a level of confidence in our data we couldn't achieve elsewhere. – Pe*Ws

Related Services

In addition to our MSC immunophenotyping service, Creative Biolabs offers a suite of complementary services to support your regenerative medicine research:

How to Contact Us

Ready to take the next step in your research? Contact our team today to learn how our MSC immunophenotyping service can benefit your project. We are here to answer your questions and provide a customized solution for your needs.

Reference

1. Ducret, Maxime, et al. "Immunophenotyping reveals the diversity of human dental pulp mesenchymal stromal cells in vivo and their evolution upon in vitro amplification." Frontiers in physiology 7 (2016): 512. Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.3389/fphys.2016.00512

For Research Use Only | Not For Clinical Use