MetaboStat™ Phase II Metabolic Stability Research Kit

CAT#: ITS-0326-YL44
Product Type: Assay Kit
Species: All Species
Brand: MetaboStat™
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Evaluates Phase II metabolic stability via UGT glucuronidation.
Brand
MetaboStat™
Development Stage
ADME
ADME Research Domain
Metabolism
Description
Designed for rigorous in vitro drug metabolism studies, this kit evaluates the Phase II metabolic stability of chemical compounds via UGT-catalyzed glucuronidation. By supplying an optimized incubation system, essential UDPGA cofactors, and validated positive controls, it bypasses complex reagent preparation. When combined with hepatic microsomes, this reliable assay ensures highly reproducible clearance evaluations, enabling scientists to efficiently characterize biotransformation pathways and optimize preclinical compound screening.
Features
Provides a comprehensive UGT incubation system with essential cofactors, streamlining assay setup to deliver highly accurate and reproducible Phase II glucuronidation stability screening.
Process Relevance
Monitoring phase II glucuronidation clearance to support structural optimization and pharmacokinetic profiling of drug candidates.
Application Stage
Drug design, lead optimization, and preclinical research
Applications
Facilitates in vitro glucuronidation assays and metabolic clearance profiling using hepatic microsomes and downstream chromatographic analysis.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Sample Type
Liver microsomes (human and various animal species)
Research Areas
Drug Metabolism; Pharmacokinetics; Pharmacology; Toxicology
Size
50 tests
Data Output Type
Quantitative chromatographic peak area
Species
All Species
Storage
Upon receipt, please follow the storage recommendations in the USER MANUAL to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. Do not store at elevated temperatures for extended periods.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on dry ice under temperature-controlled conditions.
Background
Phase II metabolism involves the enzymatic conjugation of xenobiotics or Phase I metabolites with endogenous polar molecules, such as glucuronic acid. Catalyzed predominantly by UDP-glucuronosyltransferases, this critical biological process increases compound hydrophilicity to facilitate efficient evaluation of physiological clearance mechanisms.
For Research Use Only | Not For Clinical Use
Online Inquiry