MUC1 Assay Portfolio Service
Introduction What We Can Offer Workflow Why Creative Biolabs Customer Reviews FAQs Related Services Contact Us
Creative Biolabs offers solutions for quantitative measurement of soluble MUC1, differentiation of various MUC1 isoforms and glycosylation states, robust detection and localization in tissue samples, single-cell expression analysis, and detailed protein characterization. Our expertise ensures that you overcome the inherent heterogeneity of MUC1, leading to improved assay sensitivity, specificity, and overall reproducibility. Whether your goal is to identify novel drug targets, monitor treatment efficacy, or elucidate MUC1's role in disease progression, Creative Biolabs delivers the actionable insights you need to advance your research and development.
Introduction of Tumor Target MUC1
Mucin 1 (MUC1, also known as EMA, MCA, and episialin) is a type I transmembrane glycoprotein, mainly expressed on the apical surface of most glandular epithelial cells, including the mammary gland, stomach, lung, esophagus, duodenum, pancreas and kidney, which acts as a cell surface receptor through intracellular tyrosine sites phosphorylation and interacts with various protein kinases to participate in signal transduction pathways, mediating many important cellular activities. Aberrantly expressed glycosylated MUC1 is considered to be a tumor-specific antigen on epithelial cell tumors, which has many features, such as an increase in the expression level, loss of polarity distribution, and incomplete glycosylation of the carbohydrate side chain.
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Fig.1 Different functions of MUC1 in health or cancer tissues.1
What We Can Offer
Comprehensive MUC1 & Glycosylation Analysis
Our service provides robust capabilities for detecting and characterizing all relevant MUC1 forms, including full-length protein, subunits, isoforms, and the aberrant glycosylation patterns associated with cancer.
Multi-Platform Quantitative & Qualitative Solutions
We offer a versatile portfolio for both quantitative (ELISA) and qualitative (IHC/IF) analysis. We also utilize flow cytometry and western blotting, providing a multi-dimensional view of MUC1 across a range of sample types. Our seamless integration of in vitro and in vivo platforms supports projects from initial discovery through preclinical validation.
Custom Assay Development for Unique Targets
Creative Biolabs excels in developing and rigorously optimizing custom assays for novel MUC1 epitopes, specific post-translational modifications, or challenging sample matrices. Our bespoke solutions ensure even the most niche targets can be accurately analyzed.
Guaranteed Data Quality & Accelerated Timelines
We are committed to delivering data you can trust through multi-stage validation and stringent quality control. By providing precise, timely, and comprehensive MUC1 data, our service helps you significantly accelerate your research timelines.
Workflow of MUC1 Assay Portfolio Service
Highlights
Comprehensive Solutions
Our portfolio offers a full suite of cutting-edge assays for MUC1 quantification and characterization. We integrate robust in vitro and in vivo platforms, providing a holistic approach to meet virtually any analytical need across the research spectrum.
Rigorous Validation
Every assay undergoes stringent, multi-stage validation, including comprehensive testing with diverse biological samples. We rigorously assess performance characteristics to guarantee data you can trust, consistently accounting for assay variability.
Cutting-Edge Technology
We continuously invest in state-of-the-art platforms and the latest advancements in biomarker analysis. This commitment ensures you benefit from the most advanced tools, from aptasensors for ultra-sensitive detection to automated high-throughput systems.
Collaborative Approach
We foster a true partnership, working closely with you from initial consultation through project completion. Our team engages in proactive problem-solving, ensuring a deep understanding of your goals and leading to shared scientific success.
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Customer Reviews
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Enhanced Specificity
Creative Biolabs' service significantly improved our ability to distinguish between normal and tumor-associated MUC1 isoforms, overcoming a major bottleneck that previously hindered our understanding of disease mechanisms and therapeutic development. - Dr. Jn Sh.
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Detailed Tissue Analysis
Creative Biolabs' service delivered exceptionally high-quality IHC and IF data, providing detailed spatial information. This high resolution was crucial for our mechanistic studies, allowing us to visualize MUC1 localization and its co-expression with other markers. - Dr. Ma Kr.
FAQs
How do you ensure the accuracy and reproducibility of your MUC1 assays?
All our assays undergo rigorous multi-stage validation, including testing with diverse biological samples, internal and external controls, and comprehensive quality control measures. We employ state-of-the-art instrumentation to minimize variability and ensure reliable results.
Can your service be customized for specific research needs or unique sample types?
Absolutely. Our service is highly flexible and can be fully customized. Whether you require analysis of rare sample types, detection of novel MUC1 epitopes, or integration with other experimental platforms, our team will work closely with you to design a bespoke solution.
How does Creative Biolabs' MUC1 assay portfolio service compare to standard commercial kits?
Our service provides a deeper level of expertise, customization, and comprehensive validation. We go beyond off-the-shelf solutions by offering tailored assay development for complex MUC1 forms, extensive data analysis, and expert interpretation.
Related Services
Oncology Biomarker Discovery
Identify and validate novel biomarkers beyond MUC1 to enhance your understanding of cancer biology. Our services leverage cutting-edge omics technologies combined with advanced bioinformatics and statistical analysis to discover new candidate biomarkers.
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Preclinical Efficacy Studies
Comprehensive in vivo studies to evaluate the efficacy of MUC1-targeted therapeutics in relevant animal models. Translating in vitro findings to in vivo efficacy is a critical step in drug development.
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How to Contact Us
From precise quantification and isoform differentiation to detailed functional studies, we provide the reliable data and actionable insights essential for accelerating your cancer research, drug discovery, and diagnostic development efforts. Partner with us to transform your MUC1-focused projects into impactful breakthroughs.
Contact us for more information and to discuss your project.
Reference
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Chen, Wenqing, et al. "MUC1: structure, function, and clinic application in epithelial cancers." International journal of molecular sciences 22.12 (2021): 6567. Distributed under an Open Access license CC BY 4.0, without modification. DOI: https://doi.org/10.3390/ijms22126567
