Short Description
For precise DNMT3A staining, utilize this ready-to-deploy IHC solution, simplifying procedures from antigen retrieval through coverslipping.
Description
DNA methylation in vertebrates is a key epigenetic modification crucial for embryonic development, imprinting, and X chromosome inactivation. This process is catalyzed by DNA methyltransferases (DNMTs), including DNMT1, DNMT3a, and DNMT3b. Overexpression of these enzymes has been linked to cancers like gastric, urothelial, and lung cancers, potentially driving tumorigenesis and affecting patient survival. Two isoforms of DNMT3a exist: the full-length DNMT3a and a shorter variant, DNMT3a2, which is highly expressed in stem cells and tissues undergoing de novo methylation, like the testis and ovary.
Features
Ready to use
High Sensitivity Streptavidin (HSS) increases detection sensitivity
Suitable for tissue sections & cytospin preparations
Pre-diluted reagents minimize hands-on time
Optimizes mouse, rabbit, rat, goat, or sheep IgG primary antibody staining
Reactivity
Human, Mouse, Rat
Analytical Method
Immunohistochemistry
Datasheet
