Short Description
Measures creatinine levels to assess glomerular filtration rate.
Development Stage
Research-Grade Metabolic Assay Development
Description
The OXPHOSight™ Creatinine Assay Kit offers superior sensitivity for measuring glomerular filtration rate (GFR), essential for identifying nephrotoxic side effects in early drug candidates. Optimized for micro-volume samples, it surpasses traditional methods in detecting subtle changes in kidney function. This assay is a vital component of renal clearance studies and nephrotoxicity screening in pre-clinical development.
Features
Enhanced sensitivity surpasses traditional Jaffe methods; Optimized for micro-volume samples in renal clearance and nephrotoxicity studies.
Process Relevance
Nephrotoxicity Screening
Application Stage
Pre-clinical Safety
Applications
Key tool for evaluating kidney function offering higher sensitivity than the Jaffe method.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Absorbance at 570 nm; Fluorescence Detection (Ex 530 nm / Em 585 nm)
Sample Type
Urine, serum, plasma, and other biological preparations
Research Areas
Nephrology; Toxicology
Datasheet