P450-Metric™ Cytochrome P450 Reductase (CPR) ELISA Kit

CAT#: ITS-0326-YL28
Product Type: Assay Kit
Species: Human, Rat
Brand: P450-Metric™
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Quantifies cytochrome P450 reductase using an ELISA method.
Brand
P450-Metric™
Development Stage
ADME
ADME Research Domain
Metabolism
Description
This sensitive sandwich ELISA kit provides a robust platform for quantifying cytochrome P450 reductase protein levels in various biological samples. By facilitating accurate measurement of this essential electron donor, the kit supports critical investigations into P450-mediated drug metabolism pathways. Researchers utilize this reliable tool to evaluate electron transfer efficiency, helping to characterize hepatic metabolic activity and potential drug-drug interactions within complex ADME and toxicology research studies.
Features
High-sensitivity sandwich ELISA optimized for accurate quantification of CPR, facilitating assessment of electron transfer capacity in hepatic drug metabolism studies.
Process Relevance
Standardizing electron transfer components to ensure consistent metabolic study results and optimized experimental performance.
Application Stage
Drug discovery, metabolic profiling, and toxicology research.
Applications
Quantify CPR levels in liver microsomes to evaluate electron transfer efficiency in P450-mediated drug metabolism pathways.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Sample Type
Serum, plasma, tissue homogenates, cell lysates, cell culture supernates
Research Areas
ADME; Drug Metabolism; Pharmacokinetics
Size
48 / 96 tests
Data Output Type
Absorbance (OD)
LOD
Rat: 0.124 ng/mL
Human: 0.054 ng/mL
Species
Human, Rat
Storage
Upon receipt, please follow the storage recommendations in the USER MANUAL to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. Do not store at elevated temperatures for extended periods.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on ice under temperature-controlled conditions.
Background
This enzyme serves as the obligatory electron donor for all microsomal cytochrome P450 monooxygenases. It is essential for coupling NADPH oxidation to the oxidative metabolism of a vast array of endogenous and xenobiotic substrates.
For Research Use Only | Not For Clinical Use
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