Patient derived Xenografted Modeling Service
Creative Biolabs provides a living, clinically relevant system for evaluating novel therapeutics, combination regimens, and biomarker strategies. We deliver robust in vivo efficacy data essential for critical go/no-go decisions. Our models offer unparalleled solutions for identifying drug-sensitive patient populations, validating drug targets against hard-to-treat cancer stem cells (CSCs), and rapidly deciphering mechanisms of acquired drug resistance.
Introduction What We Can Offer Workflow Why Creative Biolabs Customer Reviews FAQs Related Services Contact Us
Introduction of Patient Derived Xenografted Models
PDX models involve implanting patient tumor tissue directly into immunocompromised mice. This technique surpasses traditional cell line models (CDXs) by preserving the crucial tumor heterogeneity and the native tumor microenvironment (TME), including stroma and vasculature. Leveraging its wealth of information on more than 400 fully characterized proprietary PDX in the portfolio, Creative Biolabs is dedicated to helping scientists in immuno-oncology research and providing the most appropriate PDX models for pre-clinical testing.
Initiate a discussion - Request a scientific consultation regarding project requirements and execution.
Fig.1 The advantages of PDX over other models.
What We Can Offer
Our PDX Model Portfolio
Our PDX models offer extensive backgrounds/characterization and represent almost all tissue types and cancer types. Over 400 PDX models are available to engraft into immunocompromised mice and humanized mice and ship to your facility or to use in preclinical testing studies guided by Creative Biolabs. Our PDX model portfolio includes:
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Feature
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Feature
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Feature
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Various xenografted models, including subcutaneous, orthotopic, and disseminated models
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Extensive background on patients' treatment and molecular/pharmacological characterization
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Corresponding CDX models available
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One-stop platform from animal models to in vivo efficacy studies
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Identification and analysis of biomarkers of in-house PDX models
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PDX models using immunocompromised mice or humanized mice
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New PDX models are still being developed through continuous collaborations with major hospitals.
Our PDX Collections
Our well-characterized PDX models support the pre-clinical immuno-oncology research of more than 30 cancer types, including rare indications and highly specific molecular targets. For detailed collection information, please contact us.
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Cancer Type
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Cancer Type
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Cancer Type
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Cancer Type
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Cancer Type
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Cancer Type
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ALL
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AML
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Adrenal
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Bladder
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Brain
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Breast
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Cervical
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Cholangiocarcinoma
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Colorectal
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Esophageal
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Fallopian
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Gallbladder
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Gastric
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GIST
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Head and neck
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Kidney
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Liver
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Lung
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Lymphoma
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Melanoma
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Mesothelioma
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Mixed mullerian
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Ovarian
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Pancreatic
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Peritoneal
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Prostate
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Sarcoma
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Testis
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Thyroid
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Uterine
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PDX Establishment at Creative Biolabs
Highlights
Unrivaled Translational Fidelity
Internal validation demonstrates a concordance rate exceeding 95% between our PDX efficacy data and native tumor pathophysiology. This represents a 20× improvement in fidelity over conventional cell line models, providing a robust foundation for research decisions.
Expansive, Low-Passage Biobank
Access to a proprietary library of over 1,800 highly characterized PDX models covering the full spectrum of oncological indications, including models derived from drug-refractory and rare cancers.
Immunological Modeling Capacity
Specialized humanized mouse models facilitate the rigorous in vivo assessment of advanced immunotherapies, such as checkpoint inhibitors and CAR-T cell agents, by enabling the accurate study of complex human tumor-immune system interactions.
AI-Powered Data Integration
The application of deep learning algorithms to our comprehensive multi-omics data accelerates the objective identification of novel biomarkers and enables the creation of statistically powerful virtual control groups, optimizing experimental design and minimizing the requirement for extensive animal cohorts.
Discover how a partnership with us can streamline your research - Get a quote today.
Customer Reviews
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Target Validation
Creative Biolabs' PDX models have significantly facilitated the validation of novel immune checkpoint targets by providing a stable, immune-reconstituted model that truly reflects the patient's TME, allowing for superior comparison with traditional syngeneic models. - M. K*******n.
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Resistance Mechanisms
Using Creative Biolabs' PDX models in our research has significantly improved the rapid generation and analysis of acquired drug resistance models, allowing us to anticipate clinical failure mechanisms and develop effective combination therapies far ahead of schedule. - T. R***e.
FAQs
Q: How do you ensure the genetic stability of the PDX model, given concerns about mouse stroma taking over?
A: We stringently maintain our PDX models at low passage numbers, which is critical for preventing genetic drift and maintaining the original patient tumor heterogeneity. Furthermore, we implement routine quality control using species-specific PCR assays and IHC to confirm the ratio of human tumor cells to mouse stroma, guaranteeing the continued translational relevance of the model.
Q: Can PDX models be used for immunotherapy studies?
A: Absolutely. While standard PDX models are immunocompromised, Creative Biolabs offers specialized humanized mouse models. These models are engrafted with human immune components, providing a fully functional platform to evaluate the efficacy of immunotherapies, checkpoint inhibitors, and CAR-T cell agents under highly relevant in vivo conditions.
Related Services
GVHD Biomarker Prediction Services
A consulting and execution service specifically focused on linking drug sensitivity data from our PDX repository to specific genetic or protein expression signatures, accelerating the development of companion diagnostics.
Learn More →
Cell Line Derived Xenografted Models
Utilizing conventional CDX models for fast, cost-effective preliminary in vivo screening, providing essential PD and PK data before committing to the high-fidelity PDX pipeline.
Learn More →
How to Contact Us
Our scientists can assist in selecting the most appropriate PDX model to fit your therapy type and cancer type. Customized PDX models are also available upon request. Creative Biolabs is committed to facilitating your preclinical in vivo studies with PDX models at your fingertips. Please contact us for detailed information, and we look forward to working with you.
For Research Use Only | Not For Clinical Use
