Introduction to PDGFR and Its Therapeutic Importance

Platelet-Derived Growth Factor Receptors (PDGFR) are critical components of cellular signaling that play a pivotal role in numerous physiological processes and pathological conditions, including cancer. PDGFR consists of two primary receptor types: PDGFR-alpha and PDGFR-beta, which are activated through binding with PDGF ligands. This interaction leads to dimerization and autophosphorylation of the receptors, triggering multiple downstream signaling pathways such as PI3K/AKT, MAPK, and JAK/STAT, all contributing to cell proliferation, survival, and migration.

In cancer therapy, targeting the PDGFR signaling pathway holds immense potential due to its involvement in tumor growth, angiogenesis, and metastasis. Inhibitors have been utilized to curb PDGFR activities, arguably offering new avenues for cancer treatment strategies, particularly for malignancies that exhibit PDGFR-dependent growth, such as gastrointestinal stromal tumors (GIST) and certain leukemias.

Fig.1 PDGF signal pathways and PDGF-targeted therapy.¹

PDGFR Cell Panel Screening Service at Creative Biolabs

Creative Biolabs has been at the forefront of providing cutting-edge PDGFR Cell Panel Screening Services, designed to evaluate the efficacy of new therapeutic agents targeting PDGFR pathways. With over two decades of industry leadership, we cater to a diverse clientele, supporting the drug discovery and development processes with our robust cell panel screening solutions.

Service Packages

Our PDGFR Cell Panel Screening Service includes:

• Comprehensive Cell Line Panels:
  Creative Biolabs utilizes a diverse collection of human cancer cell lines, representing a broad spectrum of solid and hematological malignancies. This comprehensive panel allows for the assessment of drug efficacy across various tumor contexts, providing valuable insights into potential therapeutic applications and resistance mechanisms. This broad coverage is essential for identifying compounds with the greatest potential for clinical success.
• Customizable Assay Development:
  Our team of experts works closely with clients to design and implement assays tailored to specific research objectives, ensuring that the screening process aligns perfectly with their experimental design. This flexibility allows for the investigation of specific PDGFR isoforms, signaling pathway components, or downstream effects.
• Advanced Data Analytics:
  Creative Biolabs delivers detailed and comprehensive reports, including IC50 values, cell viability measurements, and other relevant metrics. Our sophisticated bioinformatics tools enable in-depth analysis of the screening data, providing valuable insights into compound potency, selectivity, and mechanism of action. We provide not just data, but actionable intelligence.

Highlights of Our PDGFR Cell Panel Screening Service

Creative Biolabs employs state-of-the-art technologies to ensure the accuracy and reliability of our screening services:

• Extensive Cell Line Panel: Hundreds of human cancer cell lines ensure coverage of a broad spectrum of cancers.
• High-throughput Screening: High-throughput screening with luminescent readouts to gauge cell viability and determine compound potency.
• Semi-Automated Processing: Ensures reproducibility and scalability of screening assays, minimizing variability and human error.

Frequently Asked Questions

Our PDGFR Cell Panel Screening Service provides a powerful tool for researchers and drug developers seeking to unlock the therapeutic potential of this critical pathway. Contact us today to learn more about how Creative Biolabs can accelerate your drug discovery efforts and help you bring innovative treatments to patients in need.

Reference

1. Sun, Yingchao, et al. "An overview of agents and treatments for PDGFRA-mutated gastrointestinal stromal tumors." Frontiers in Oncology 12 (2022): 927587. Distributed under Open Access License CC BY 4.0, without modification.

For Research Use Only | Not For Clinical Use