Human Ovary Cell SK-OV-3

The SK-OV-3 cell line originates from human ovarian adenocarcinoma. Under microscopic observation, SK-OV-3 cells typically exhibit a polygonal or flattened morphology with irregular cell edges. This cell line is extensively utilized in cancer research, especially for investigating the effects and mechanisms of candidate anti-cancer compounds. The SK-OV-3 cell line has the following characteristics:

• Drug Resistance: SK-OV-3 cells exhibit resistance to various cytotoxic drugs, making it an important model for studying cancer drug resistance mechanisms.
• Growth Characteristics: SK-OV-3 cells can proliferate rapidly in vitro, making them suitable for various laboratory studies.
• Cell Cycle: This cell line shows sensitivity to microtubule dynamics during the cell cycle and is commonly used to study the effects of anti-cancer drugs on cell cycle progression.
• Wide Application: The SK-OV-3 cell line is widely used in cancer research, particularly in evaluating the anti-cancer activity and mechanisms of new drugs.

Fig. 1 SK-OV-3 was used as a model to observe the effects of viriditoxin on microtubule dynamics.¹

SK-OV-3-based Proliferation Assay

The SK-OV-3 cells are resistant and can withstand various cytotoxic drugs, making them suitable for evaluating the effectiveness of test compounds in cancer treatment. They can be used to evaluate the inhibitory effects of these compounds on the migration and colony formation ability of ovarian adenocarcinoma, demonstrating their potential in suppressing cancer cell metastasis.

Creative Biolabs offers SK-OV-3-based proliferation assay for test compounds. The SK-OV-3-based proliferation assay allows for the evaluation of different compounds' effects on cell proliferation, offering insights into the relative potency and mechanisms of various therapeutic agents.

You might also be interested in another proliferation assay involving a different ovary cell line OVCAR-3. Looking forward to you contacting us for more information and more proliferation assays involving other cells.

Reference

1. Su, M., et al. "Viriditoxin Stabilizes Microtubule Polymers in SK-OV-3 Cells and Exhibits Antimitotic and Antimetastatic Potential." Marine Drugs 18.9 (2020): 445. Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only | Not For Clinical Use