As scientists continue to unravel the complexities of cellular signaling pathways, the STAT pathway has emerged as a critical target for innovative therapeutic interventions. At Creative Biolabs, we are at the forefront of this research, offering our cutting-edge STAT reporter panel screening service to accelerate the discovery and optimization of antibody and protein therapeutics.

Understanding the Significance of STAT Pathways

The STAT pathway is a crucial cellular signaling mechanism that plays a significant role in various biological processes, including growth, survival, differentiation, and immune response regulation. Activated by cytokines and growth factors, this pathway involves the phosphorylation of STAT proteins, which then dimerize and translocate to the cell nucleus to influence gene expression. Dysregulation of STAT proteins is associated with numerous diseases. Therefore, understanding the STAT pathways is essential in the development of therapeutic strategies aimed at modulating these pathways for disease treatment and prevention. Recognizing the importance of this pathway, Creative Biolabs has developed specialized STAT reporter panels.

Fig.1 STAT pathway activated by cytokine signaling.¹

High-Throughput Screening for Potential Inhibitors

STAT proteins are essential in the JAK-STAT signaling pathway, which transmits extracellular signals to the cell nucleus, regulating gene expression. In order to identify potential drug candidates, our platform employs high-throughput screening methodologies. This approach efficiently screens enzyme inhibitors at the cellular level, pinpointing candidates with substantial activity. By focusing on the interactions between cytokine receptors and the JAK kinases, as well as various STAT proteins, our screening panels are adept at identifying inhibitors relevant to the cytokine receptor, JAK, and STAT pathways.

Our high-throughput assay platform allows for the simultaneous evaluation of numerous candidates, significantly accelerating the discovery process. This capability is crucial for identifying promising candidates from large libraries of potential therapeutics.

Innovative Cell-Based Reporter Assays

Our STAT reporter panels utilize cell-based reporter assays that specifically target a range of STAT proteins, including STAT1, STAT3, STAT4, STAT5, and STAT6. These assays are tailored to provide insights into the activity and efficacy of antibody and protein therapeutics. The use of cell-based models enables real-time analysis of drug interactions within a physiological context, providing robust and relevant data.

Our unique suite of reporter cells, developed from specific cytokine receptors and related genes, enhances our capability to screen for pathway-specific inhibitors. This includes the identification and validation of promising lead candidates, thus expediting the drug development process.

Partner with Creative Biolabs for Cutting-Edge Screening Solutions

At Creative Biolabs, we are committed to advancing the field of therapeutic antibody and protein development through our state-of-the-art screening services. Our cellular functional selectivity panels offer researchers an unparalleled tool to unlock the therapeutic potential of their drug candidates. Feel free to reach out to us today to learn more about how our innovative screening solutions can support your scientific endeavors.

Reference

1. Sarapultsev, Alexey, et al. "JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions." Molecular biomedicine 4.1 (2023): 40. Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only | Not For Clinical Use