Webinar: Reshaping the Immune Response Through Biomolecular Engineering
Time: 10:00 AM EST, November 25, 2026
Protein therapeutics have transformed the treatment landscape for cancer, autoimmune disorders, and many other diseases. Yet naturally occurring proteins often have limitations that restrict their therapeutic utility. Many immune molecules, including cytokines, growth factors, and antibodies, can trigger multiple biological effects at once, making it difficult to achieve the desired therapeutic activity without unwanted toxicity or reduced efficacy.
As our understanding of protein structure–function relationships continues to advance, researchers are increasingly moving beyond unbiased engineering approaches toward more rational, mechanism-driven strategies. By integrating structural biology, molecular design, and biomolecular engineering, it is now possible to redesign existing proteins or create new molecules with improved specificity, activity, and therapeutic potential.
Creative Biolabs is pleased to host an expert webinar featuring Jamie Spangler, Ph.D., Associate Professor of Biomedical Engineering and Chemical & Biomolecular Engineering at Johns Hopkins University. In this webinar, Dr. Spangler will discuss how structure-based engineering can be used to uncover the mechanistic determinants of protein activity and guide the development of next-generation molecular immunotherapeutics.
The talk will highlight ongoing work from the Spangler Lab spanning the discovery, design, and translation of engineered immune proteins for applications in cancer, autoimmune disorders, and regenerative medicine.
Why Attend?
The rapid growth of protein drugs has created new opportunities for therapeutic innovation, but major challenges remain. Delivery barriers, acquired resistance, off-target activity, and toxicity continue to limit the full potential of many biologic therapies.
For researchers working in immunotherapy, antibody engineering, cytokine biology, protein design, or translational therapeutics, a deeper understanding of how molecular structure governs immune function is essential. Structure-guided biomolecular engineering provides a powerful framework for designing proteins that can more precisely modulate immune responses and address clinically unmet needs.
This webinar will provide expert insights into how engineered immune molecules can be designed to bias immune activity, improve therapeutic selectivity, and support the development of more effective biologic therapies.
What You Will Learn
During this webinar, you will learn:
- How structure–function relationships can guide the engineering of therapeutic proteins
- Why naturally occurring immune proteins may have limitations as therapeutic agents
- How cytokines, growth factors, and antibodies can be redesigned to modulate immune responses
- How structural biology and molecular design can inform protein engineering strategies
- How engineered immune molecules may support targeted treatment of cancer and autoimmune disorders
- How biomolecular engineering can help address challenges such as toxicity, resistance, and limited therapeutic specificity
- How discovery, design, and translational strategies can be integrated to advance novel molecular immunotherapeutics
Who Should Attend?
This webinar is especially relevant for:
- Scientists working in protein engineering, antibody engineering, cytokine biology, or molecular design
- Researchers developing biologic therapies for cancer, autoimmune disorders, or inflammatory diseases
- Immunology and immunotherapy researchers interested in immune modulation strategies
- Biotech and pharmaceutical R&D teams focused on therapeutic protein discovery and optimization
- Scientists involved in translational therapeutics, structural biology, or regenerative medicine
- Academic and industry professionals seeking new approaches to improve the precision and performance of protein-based therapies
Featured Speaker
Jamie Spangler, Ph.D.
Associate Professor
Biomedical Engineering
Chemical & Biomolecular Engineering
Johns Hopkins University
Dr. Jamie Spangler is an Associate Professor of Biomedical Engineering and Chemical & Biomolecular Engineering at Johns Hopkins University. Her research group applies structural and mechanistic insights to re-engineer existing proteins and design new molecules that therapeutically modulate the immune response.
The Spangler Lab focuses on engineering immune proteins, including cytokines, growth factors, and antibodies, for targeted treatment of diseases such as cancer and autoimmune disorders. By combining structural biology, molecular design, and protein engineering, her team works to uncover the mechanisms that determine protein activity and translate these insights into novel therapeutic strategies.
Dr. Spangler earned her B.S. in Biomedical Engineering from Johns Hopkins University and her Ph.D. in Biological Engineering from MIT. She completed postdoctoral training at Stanford University School of Medicine before launching her independent research group at Johns Hopkins University in 2017.
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