Recombinant CD20 Protein (Full Length) [His] (VAng-1214Lsx)

Human CD20, His tag, is expressed in HEK 293 cells. (Uniprot ID: P11836-1)

Datasheet

Specifications

Source

HEK293 Cells.

Target

CD20

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

50 mM HEPES, 150 mM NaCl, DDM, CHS, pH 7.5.

Purity

> 80% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The protein has no known natural ligand and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that it acts as a calcium channel in the cell membrane. CD20 is expressed on all stages of B cell development except the first and last; it is present from late pro-B cells through memory cells, but not on either early pro-B cells or plasma blasts and plasma cells.

Alternative Names

MS4A1, CD20, MS4A-1