Recombinant CD20 Protein (Full Length) [His] (VAng-1214Lsx)
Human CD20, His tag, is expressed in HEK 293 cells. (Uniprot ID: P11836-1)
Datasheet
Specifications
Source
HEK293 Cells.
Target
CD20
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
50 mM HEPES, 150 mM NaCl, DDM, CHS, pH 7.5.
Purity
> 80% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The protein has no known natural ligand and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that it acts as a calcium channel in the cell membrane. CD20 is expressed on all stages of B cell development except the first and last; it is present from late pro-B cells through memory cells, but not on either early pro-B cells or plasma blasts and plasma cells.
Alternative Names
MS4A1, CD20, MS4A-1
Related Product
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