With extensive experience and advanced antibody libraries, we offer a well-established phage display platform to our clients for antibody screening with high antigen specificity and binding affinity.
ADC Antibody Screening Service
To avoid the severe side-effects due to lack of target specificity caused by conventional cancer therapies such as chemotherapy, radiation therapy, and surgery, Creative Biolabs is dedicated to targeted therapies, especially antibody-drug conjugates (ADC) that can improve the safety and efficacy to treat cancer. We have exploited a comprehensive ADC platform, including ADC antibody screening, conjugation chemistry, linker and payload service, analytical characterization and validation, fill and finish, etc., to facilitate your ADC discovery and development.
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Introduction to ADC Antibody Screening
Fig.1 Structure of ADC.
ADC Antibody Screening is the laboratory process of selecting monoclonal antibodies specifically for their ability to deliver cytotoxic payloads into target cells. Effective candidates require sufficient antigen expression and rapid internalization kinetics to achieve research success. Creative Biolabs' platform addresses the challenges of "Payload-Induced Aggregation" and "Decoy Binding" by screening for membrane-anchored targets with high specificity. Our methodology ensures that the antibody, linker, and payload function as a unified research unit.
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What We Can Offer
With the toxic payload linked to a monoclonal antibody that is specific for the target antigen, ADC can specifically deliver the toxic payload into the target tumor cells, which can ideally eliminate the payload toxicity to healthy tissues. Most of the toxic payloads play the functional role by disrupting important cellular pathways; hence, antibody internalization is critically important for good ADC efficacy through receptor-mediated endocytosis.
Fig.2 The process of ADCs exerting activity. 1
Tumor Antigen Identification
Creative Biolabs offers the ADC antibody screening service to help you identify the appropriate tumor antigen as per the following stringent criteria.
- To allow efficient ADC binding, the antigen should be in an appropriate cell surface localization.
- To ensure high specificity and efficacy, the antigen should be specific for tumors rather than healthy tissues.
- If no tumor-specific antigen is identified, the antigen with much higher expression compared to that in normal tissues can be considered.
- To ensure ADC incorporation through receptor-mediated endocytosis when ADC binds, internalization of the antigen should be considered.
Antibody Screening
Once the tumor antigen is identified, Creative Biolabs offers extensive screening to get a few suitable monoclonal antibodies with specific target recognition capability for ADC development.
We offer a series of antibody engineering services, such as an antibody humanization service to engraft the appropriate CDR regions into a suitable human framework for ADC development.
Except for high specificity and binding affinity, a strong tendency for internalization is a must for a successful ADC once binding to an antigen. We offer unique internalizing antibody screening services to screen for 'internalizing' antibodies through pH-sensitive dye, fluorescent labeling, etc.
Anti-Ab ADC
We also offer a unique Anti-Ab ADC service to evaluate the internalization abilities of targeted antibodies by assessing the toxic effects generated by Anti-Ab ADC. We aim to select the best ADC antibodies for your project.
How Creative Biolabs' service Can Assist Your Projects
Highlights
Advanced Discovery Platforms
We utilize sophisticated methodologies to identify high-affinity binders, ensuring a diverse pool of leads that traditional screening techniques often fail to capture.
Development Solutions
Our team provides end-to-end support for your project, from initial target identification to the delivery of optimized, research-grade antibody candidates.
Multidisciplinary Technical Expertise
We integrate a broad range of scientific disciplines to solve complex biophysical challenges, ensuring your candidates possess ideal characteristics for further research.
Strategic ADC Prioritization
Unlike general providers, we focus on biological fitness from the start, prioritizing candidates with rapid internalization and exceptional structural stability profiles.
Discover how a partnership with us can streamline your research - Get a quote today.
Customer Reviews
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Superior Internalization Insights
Using Creative Biolabs' ADC antibody screening in our research has significantly improved our ability to distinguish between surface-bound and internalizing antibodies, a bottleneck we faced for years. - Dr. J**s. H. -
Excellent Payload Stability Data
The developability suite provided by Creative Biolabs was critical; it helped us avoid an antibody that aggregated upon conjugation, saving us significant time in downstream research. - Dr. R**t. M.
FAQs
Can you screen for targets with low expression levels?
While high expression is ideal, we utilize high-potency payloads and advanced internalization screening to maximize the experimental window for lower-abundance targets.
What is the benefit of the Anti-Ab ADC assay?
It allows us to test the potential cytotoxic effects of hundreds of antibodies without the high cost of custom conjugation for every lead, significantly accelerating your research timeline.
Related Services
Antibody Screening & Characterization Service
We provide specialized functional analysis and high-throughput screening to identify potent antibody binders for various immune-oncology research targets.
Learn More →Antibody Engineering Services
We offer advanced modifications, including affinity maturation and bispecific formatting, to enhance the targeting precision and therapeutic potential of your research-grade antibodies.
Learn More →How to Contact Us
With advanced antibody screen platforms and extensive experience in ADC design, production, and analysis, Creative Biolabs is fully competent in ADC antibody screening. We are committed to being your best partner in ADC discovery and development and facilitating your project with our professional expertise. For more information or a detailed quote, please don't hesitate to contact us.
Reference
- Tang, Haichao et al. "The Analysis of Key Factors Related to ADCs Structural Design." Frontiers in pharmacology vol. 10 373. 24 Apr. 2019. Distributed under an Open Access license CC BY 4.0, without modification. https://doi.org/10.3389/fphar.2019.00373
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