We manage the entire pipeline from initial enrichment and enumeration to downstream single-cell multi-omics and bioinformatics, providing a unified data stream for your research project.
Circulating Tumor Cell Enumeration & Molecular Profiling Service
Creative Biolabs offers an end-to-end service for the isolation and deep molecular characterization of circulating tumor cells. We provide researchers with the tools to detect rare cells and analyze their genetic and proteomic signatures. By choosing our service, clients gain access to longitudinal data that reveals the shifting landscape of a tumor over time, rather than a single static point. This allows for more informed decisions in drug development and a clearer understanding of the mechanisms behind therapeutic resistance.
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CTC Enumeration and Molecular Profiling Service Overview
As the primary vectors of metastasis, Circulating Tumor Cells (CTCs) represent a vital yet elusive research target due to their extreme rarity. Established research recognizes CTCs as significant markers of disease progression. By capturing these intact units, Creative Biolabs facilitates the comparative study of circulating cellular profiles against primary tumor data. This high-fidelity isolation provides researchers with more relevant biological targets, ultimately enhancing the development of next-generation oncology therapies and drug discovery initiatives.
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Fig.1 Overview of the metastatic cascade. 1
What We Can Offer
One-stop CTC solution
Customized biomarker panels
Our team designs bespoke panels to detect specific research targets or resistance markers using multi-color immunofluorescence, ensuring the assay aligns perfectly with your study objectives.
Marker-independent enrichment capabilities
We utilize advanced technologies to capture cells undergoing transition (EMT-phenotype), ensuring that diverse clones and highly invasive sub-populations are thoroughly analyzed without epithelial bias.
Scalable research support
Our infrastructure provides the capacity to process high volumes of samples for large-scale studies, maintaining consistent quality and rapid turnaround times for multi-center research initiatives.
How Creative Biolabs Can Assist Your Project
Highlights
Technical Leadership
Creative Biolabs stands at the intersection of biological expertise and technological innovation, utilizing proprietary platforms to isolate rare cells with high efficiency for various oncology research projects.
Cellular Priority
While many providers focus solely on DNA fragments, we prioritize the intact cell, providing functional protein data and morphological insights that are essential for high-impact research.
Validated Performance
Our specialized platforms have been validated against various data sets, demonstrating high recovery rates of rare cells even in low-density samples, ensuring reliable results for every study.
Protocol Excellence
We ensure that your project benefits from refined protocols that protect cell viability and RNA stability, maintaining molecular integrity for up to 96 hours to facilitate global logistics.
By integrating our high-sensitivity enrichment platforms with longitudinal profiling, you gain an unparalleled advantage in tracking clonal evolution and validating novel targets - Get a Quote Today.
Customer Reviews
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High Sensitivity for Transitioning Cells
The sensitivity in capturing transitioning cells has been impressive. Using Creative Biolabs' CTC service in our lung cancer research has improved our ability to track specific markers that were previously missed by standard platforms. - Dr. Michael S***n -
Superior Protein Localization Insights
This service facilitated our understanding of protein localization on CTCs, which provided a clear advantage over simple fragment sequencing during our biomarker validation. - Dr. E**a V.
FAQs
How do CTCs compare to ctDNA for monitoring research models?
While ctDNA excels at detecting genomic mutations, CTCs enable functional protein analysis and morphological assessment, offering a biological perspective of resistance mechanisms essential for research projects.
Can you detect CTCs in early-stage research models?
Yes. Our enrichment is designed for research involving minimal residual disease where cell counts are low, providing predictive value for monitoring recurrence in various oncology models.
Related Services
Biomarker Development Service
We provide end-to-end identification, validation, and screening services for novel oncology targets, utilizing high-throughput platforms to accelerate discovery through precise molecular characterization and functional research assays.
Learn More →Single-Cell & Spatial Mapping Service for Metastatic Ecosystem
This integrated platform provides high-resolution spatial transcriptomics and single-cell sequencing to resolve the complex cellular architecture and metabolic interactions within the metastatic microenvironment during research.
Learn More →How to Contact Us
Creative Biolabs provides a circulating tumor cell enumeration & molecular profiling service that transforms a blood sample into a high-fidelity map of tumor evolution. By combining high-sensitivity enrichment with molecular characterization, we empower our partners to make faster decisions in their research and development pipelines.
For technical specifications, project pricing, or to speak with a scientist about your specific requirements, please get started today.
Reference
- Chemi, Francesca et al. "Early Dissemination of Circulating Tumor Cells: Biological and Clinical Insights." Frontiers in oncology vol. 11 672195. 7 May. 2021. Distributed under an Open Access license CC BY 4.0, without modification. https://doi.org/10.3389/fonc.2021.672195
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