FluxControl™ CAR (NR1I3) ELISA Kit

CAT#: ITS-0326-YL41
Product Type: Assay Kit
Species: Human, Rat, Mouse
Brand: FluxControl™
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Quantifies CAR protein using a sandwich ELISA method.
Brand
FluxControl™
Development Stage
ADME
ADME Research Domain
Metabolism
Description
Designed for high performance, this sandwich ELISA kit allows for the reliable quantification of the CAR nuclear receptor. The assay is an excellent resource for evaluating the receptor's role in the xenosensor-mediated regulation of various hepatic drug-metabolizing enzymes and transporters. By providing precise protein expression data, researchers can gain valuable insights into the regulatory networks that govern metabolic drug clearance and complex enzyme induction processes.
Features
High-performance CAR ELISA for reliable receptor quantification, facilitating deep insights into xenosensor-driven regulation of hepatic drug-metabolizing enzymes and transporters.
Process Relevance
Assessing CAR protein levels to optimize regulatory network studies and improve consistency in enzyme induction models.
Application Stage
Drug discovery, mechanistic studies, and safety assessment.
Applications
Quantify CAR expression to evaluate its role in the xenosensor-mediated regulation of hepatic drug-metabolizing enzymes and transporters.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Sample Type
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Research Areas
ADME; Drug Metabolism; Pharmacokinetics
Size
96 tests
Data Output Type
Absorbance (OD)
LOD
Rat: 0.079 ng/mL
Human: 0.15 ng/mL
Mouse: 0.18 ng/mL
Species
Human, Rat, Mouse
Storage
Upon receipt, please follow the storage recommendations in the USER MANUAL to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. Do not store at elevated temperatures for extended periods.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on ice under temperature-controlled conditions.
Background
This nuclear receptor acts as a xenosensor, regulating hepatic genes involved in both phase I and phase II metabolism. It plays a critical role in the adaptive response to diverse pharmacological agents and endobiotics.
For Research Use Only | Not For Clinical Use
Online Inquiry