High Content Screening (HCS) is a key high-throughput analytical technique to assess complex cell parameters for biomedical research and drug discovery. Using automated microscopy in conjunction with advanced image processing algorithms, HCS allows researchers to watch complex cellular behavior, phenotype, and treatment effects in real time. It is important for applications in oncology, neurobiology, toxicology, and regenerative medicine, where it's important to grasp multi-scale cellular responses. HCS enables multiple features to be assessed simultaneously at the cell level, providing a quantitative picture of biology and drug interactions at the cell level.
Creative Biolabs leverages this innovative technology to create customized HCS assays for rigorous scientific research in a range of areas. With combined experience in bioinformatics, disease biology, and image analysis, Creative Biolabs provides HCS services to create robust, scalable data for clients around the world.
Fig.1 Evolution of High Content Imaging Hardware and Software Solutions.1
HCS Workflow
The HCS assay pipeline at Creative Biolabs is a structured and streamlined process designed to ensure consistent, reproducible results. Each phase is executed with precision, from assay design and optimization to data interpretation. The process includes the following key steps:
Fig.2 HCS Workflow at Creative Biolabs.
Our HCS Services
We offer both small-scale screening and large-scale screening options tailored to your research. The small-scale screens are ideal for early-stage research, allowing clients to fine-tune assay parameters before expanding to larger studies. While the large-scale screening capabilities are crucial for our clients aiming to generate large datasets for applications such as drug screening, toxicology, and biomarker identification.
Small-Scale Screening Options
For initial studies or validation projects, Creative Biolabs offers small-scale screening options that provide a foundation for assay development and optimization. These services include:
Training on HCS instruments and analysis software.
Custom image analysis for assay development, optimization, and data validation.
Specialized support for assay readout optimization, ensuring clear and reliable measurements.
Large-Scale Screening Capabilities
Creative Biolabs also supports high-throughput, large-scale screening for comprehensive data acquisition and high-volume analysis. Key capabilities include:
Assay miniaturization and algorithmic optimization to facilitate large-scale studies.
Integration with HTS facilities to enable expansive, automated data collection.
Advanced data management and analysis tools that maintain accuracy and consistency across high sample volumes.
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Applications
Example Assays
Cell Health & Apoptosis
Apoptosis, Mitochondrial Health, Steatosis
Metabolic Activity
Fat Formation, Lipolysis, Angiogenesis
Cell Structure & Movement
Cell Migration, Cell-Cell Junction, Cytoskeletal Rearrangement, Cell Movement
Signal Transduction
MAP Kinase Pathway, Wnt Signal, Receptor Internalization, Protein Acetylation
Neurobiology
Neuronal Differentiation, Neural Crest Migration, Neurological Function
Cellular Processes
Autophagy, Protein Aggregation, Epigenetic Modification, Subcellular Localization
Advanced Imaging
Real-Time Imaging (Ca Flux), Marker Expression, Transcription Factor Translocation
Pathogen Studies
Virus Replication
Why Choose Creative Biolabs for High Content Screening?
Customized HCS Assays
Tailored assays for research goals
Proprietary imaging algorithms for accuracy
Comprehensive Assay Portfolio
Over 100 HCS assays available
Covers apoptosis to pathway analysis
Advanced Technology
High-throughput imaging systems
Supports small and large-scale studies
Expert Support
Assistance in assay design and optimization
In-depth data interpretation
Streamlined Project Management
Single point of contact for clients
Efficient communication and insights
Flexible Research Solutions
Customizable for diverse research needs
Reliable results with precise quantification
For more details, please feel free to contact us or send us a query directly.
Reference
Way, Gregory P., et al. "Evolution and impact of high content imaging." Slas Discovery 28.7 (2023): 292-305. Distributed under Open Access license CC BY 4.0, without modification.
Fig.1 Evolution of High Content Imaging Hardware and Software Solutions.1
Fig.2 HCS Workflow at Creative Biolabs.
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