In Vivo Efficacy

With the rapid development of various immunotherapies, especially the approved immune checkpoint inhibitors and adoptive transfer immune cell therapies, the discovery and development of potential anticancer immunotherapy approaches have become a promising direction. Creative Biolabs is dedicated to offering a comprehensive set of independent or integrated services to support pre-clinical testing, including in vivo efficacy evaluation.

Oncology In Vivo Efficacy Studies

As an end-to-end solution provider and concentrated CRO in cancer immunotherapy discovery and development, Creative Biolabs offers our clients with a comprehensive suite of validated in vivo cancer efficacy studies to advance their pre-clinical development projects in a cost-effective and timely manner. We are committed to helping you to choose the most appropriate immuno-oncology animal models, study designs, and screening assays matched to your potential immunotherapy candidates, including checkpoint inhibitors, co-stimulatory agonists, oncolytic viruses, therapeutic engineered immune cells, cytokines and antibodies.

We offer a wide range of anti-tumor studies to evaluate the anti-tumor activities including:

• Tumor volume and growth curve;
• Tumor recurrence and metastasis;
• Survival curve;
• Cytokine production;
• Evaluation of tumor infiltrating lymphocytes, macrophages, dendritic cells, etc.
• Hematology (CBC/Diff) analysis;
• Biomarker evaluation.

Specific efficacy approaches are utilized to evaluate the above anti-tumor activities but are not limited to these. For specific assays or methods which are not included here, please contact us for a customized solution.

• Flow immune-cytometry
• ELISPOT assay
• Bioluminescence imaging and immunofluorescence
• Histopathological analysis or tissue sampling
• Immunohistochemistry analysis
• Wright-Giemsa staining of the peripheral blood

The Best Helper to Accelerate Your Anti-Tumor Efficacy Evaluation,
The Valuable Cooperator to Innovate Your Cancer Immunotherapy Drug Candidate to Market Faster!

Our broad range of in vivo efficacy assays ensure a wide variety of testing alternatives for your agents. In this diverse field of cancer therapy, we understand that the above studies will not meet all needs, therefore we are always under development with a wide range of novel assays to evaluate the pre-clinical efficacy data of the immunotherapy approaches. We will work closely with you to customize a specific integrated assay package to best fit your program.

Highlight Features

• Covering almost all cancer types for xenograft models;
• Reproducible and accurate efficacy data;
• Regulatory experts’ guidance to ensure compliance.

With extensive experience and experienced technicians, Creative Biolabs has established a comprehensive immuno-oncology efficacy platform to facilitate in vivo efficacy evaluation for new potential immunotherapies. Please don’t hesitate to contact us for detailed information.