Creative Biolabs offers Human CD4+//CD45RO+ Memory T Cells for a wide variety of function assays.
Description
Human CD4+//CD45RO+ memory T cells are a subset of memory T cells that are distinguished by the expression of two cell surface markers - CD4 and CD45RO. CD4 is a co-receptor that helps T cells recognize antigens presented by antigen-presenting cells, while CD45RO is a marker for memory T cells. Human CD4+//CD45RO+ memory T cells play a key role in the adaptive immune response, providing protection against pathogens that the immune system has encountered before.
Background
CD4+ cells, also known as T-helper cells, are a type of white blood cell that play a critical role in the functioning of the immune system. These cells are responsible for coordinating the immune response by activating and directing other immune cells to defend against pathogens such as bacteria, viruses, and other foreign invaders. CD4+ cells also play a key role in adaptive immunity, a specific immune response that develops after exposure to a pathogen to provide long-lasting protection against future infections. In individuals with human immunodeficiency virus (HIV), the virus specifically targets and infects CD4+ cells, leading to a weakening of the immune system and increased susceptibility to infections.
Species
Human
Cell Type
T cells
Source
PBMC
Culture medium
PRMI1640
Features
High quality; High viability; Widely applications.
Donor Health
Healthy
Additional Donor Information
Contact us for donor specifications (Age,Gender,BMI category, smoking status, ethnicity, etc.).
Formulation
Contains Cryopreservation Medium
Cell Purity
> 80%
Cell Viability
> 80%
Mycoplasma Testing
Negative
Sterility Testing
Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.
Genetic Stability Testing
We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.
Preparation
All cells were collected under Institutional Review Board (IRB)-approved consent forms and protocols.
Application
Immunotherapy Discovery and Development
Quality Control
Donors are negative for HIV-1, HIV-2, hepatitis B, and hepatitis C.
Storage
Stored at < -120°C once they are received.
Handling Notes
Frozen cells should be thawed according to handling procedure or stored in a liquid nitrogen tank.
Warnings
Avoid multiple freeze/thaw cycles.
Size
1 x 10e6 cells/vial
Status
Frozen
Note
Certain products are only available in select territories. Please contact us for more information.