PharmaOnco™ Human Effector Memory CD8+ T Cells

CAT#: ITS-0622-YT541
Product Type: Primary human cells
Cell Type: Effector memory CD8+ T cells
Species: Human
Short Description
Creative Biolabs offers Human Effector Memory CD8+ T Cells for immunity reaserch.
Description
Effector memory CD8+ T cells are a subset of memory T cells that have previously encountered and responded to a specific antigen. These T cells are characterized by their ability to quickly produce effector molecules such as cytokines and cytotoxic granules upon re-exposure to the same antigen. Effector memory CD8+ T cells play a crucial role in immune responses against pathogens and tumors, as they are able to provide rapid and effective protection against recurring threats.
Background
Memory CD8+ T cells were originally thought to exist as two populations (effector and central memory). Effector memory CD8+ T cells lack expression of CCR7 and CD62L, displaying receptors that promote the migration back and from other tissues and have a better ability to readily produce cytokines. It reside in or circulate through peripheral tissues, such as the lung and skin, and have rapid and potent ex vivo cytotoxic T lymphocyte (CTL) activity.
Species
Human
Cell Type
Effector memory CD8+ T cells
Source
Peripheral Blood
Features
High quality;
High viability;
Widely applications.
Donor Health
Normal
Anticoagulant
Acid-citrate-dextrose solution A (ACDA)
Additional Donor Information
Contact us for donor specifications (Age,Gender,BMI category, smoking status, ethnicity, etc.).
Formulation
Contains Cryopreservation Medium
Cell Purity
>90% CD3+CD8+CD45RO+ by flow cytometry immediately after isolation,>85% CD62L-CD45RO+ (as a percentage of CD8+CD3+ cells) by flow cytometry after 24 hours in culture
Mycoplasma Testing
Negative
Sterility Testing
Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.
Genetic Stability Testing
We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.
Application
Immunotherapy Discovery and Development
Quality Control
Donors are screened for HIV-1, HIV-2, hepatitis B, and hepatitis C.
Storage
Store at -135°C or colder for 12 months from date of receipt.
Handling Notes
When handling biohazardous materials such as human cells, safe laboratory procedures should be followed and protective clothing should be worn.
Warnings
Creative Biolabs cannot guarantee the biological function or any other properties associated with performance of this product in a researcher's individual assay or culture systems.
Size
1 x 10e6 cells/vial
Status
Frozen
Note
Certain products are only available in select territories. Please contact us for more information.
For Research Use Only | Not For Clinical Use
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