Short Description
Determines AChE activity based on thiocholine production.
Development Stage
Research-Grade Protein & Enzyme Assay Development
Description
The ModifiSite™ Acetylcholinesterase Assay Kit is a standard tool for screening AChE inhibitors, which are the primary therapeutic class for Alzheimer's disease management. This colorimetric assay validates compounds that enhance cholinergic transmission, supporting neuropharmacology research. It is also used in toxicology to detect exposure to organophosphate pesticides and nerve agents.
Features
Colorimetric method based on Ellman's reagent; Standard tool for screening Alzheimer's disease therapeutics.
Process Relevance
Neurotoxicity & Alzheimer's Screening
Application Stage
Hit-to-Lead Screening
Applications
Neurotoxicity testing and Alzheimer's disease research.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Absorbance at 412 nm
Sample Type
Blood, serum, plasma samples
Research Areas
Neuroscience; Toxicology
Datasheet