AccuMetab™ Human CYP46A1 Enzyme, Catalytically Active

CAT#: ITS-0426-YL15
Product Type: Recombinant Phase I Metabolizing Enzyme
Brand: AccuMetab
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Human CYP46A1 for accurate Phase I drug metabolism profiling.
Brand
AccuMetab
Development Stage
ADME
ADME Research Domain
Metabolism
Background
Strictly expressed in the central nervous system, CYP46A1 regulates brain cholesterol homeostasis by catalyzing its conversion to 24S-hydroxycholesterol. This enzyme is a critical focal point in neuropharmacology for assessing the clearance of CNS-targeted drugs and understanding neurodegenerative disease mechanisms.
Key Features
Proprietary E. coli expression; High and low reductase ratio options; Specifically regulates brain cholesterol homeostasis; Crucial for CNS and neuropharmacology drug scaling
Applications
Drug Metabolism Studies, Reaction Phenotyping, DDI Assessment, Metabolite ID
Research Areas
ADME; Neurology
Species
Human
Expression System
Recombinant enzymes prepared from E. coli and co-expressed with NADPH CYP-reductase.
Physical Form
Liquid
Size
0.5 nmol; 1 nmol; 4 nmol; 10 mg
Storage
-80°C
Storage Comment
When stored at -80°C, our product remains stable and retains full functional activity for up to 10 years.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Our enzyme products are shipped at -80°C.
For Research Use Only | Not For Clinical Use
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