Protein Disulfide-Isomerase-targeted RNA Modification and Metabolomics Analysis Tool

CAT#: ITS-0524-CR287
Cell Type: M1 macrophages
RNA writers: METTL14
RNA readers: YTHDF2
RNA erasers: ALKBH5
Enzymes: ACSS2
RNA types: tRNA
Modification: ac4C
RNA editing: C to U
Short Description
This product is a Protein disulfide-isomerase-targeted RNA modification and metabolomics analysis tool based on the ac4C (METTL14-YTHDF2-ALKBH5-ACSS2-spacer C9) modification and TCA cycle-mediated (RBFOX1-Succinyl-CoA-α-KG) metabolic analysis system.
RNA writers
METTL14
RNA readers
YTHDF2
RNA erasers
ALKBH5
Enzymes
ACSS2
RNA types
tRNA
Modification
ac4C
Label
spacer C9
RNA editing
C to U
Cell Type
M1 macrophages
Oligonucleotide
2'-OMe, 2'dT (LNP)
RNA Construction
tRNA-ac4C-METTL14-YTHDF2-ALKBH5-ACSS2-spacer C9
Substrates
Succinyl-CoA
Cofactors
α-KG
Pathway
TCA cycle
Epigenetic regulator
PKCλ/ι deficiency
Metabolic alteration
Favor the development of NEPC characteristics
Targeting diseases
Renal and Bladder Cancers
RNA-binding proteins
RBFOX1
Metabolic Reprogramming
TCA cycle-RBFOX1-Succinyl-CoA-α-KG
Target
Protein disulfide-isomerase
Alternative Names
Protein disulfide-isomerase
Format
Liquid
Shipping
All ordered products are shipped from Fedex or UPS.
Handling Advice
Prevent prolonged exposure to light.
Storage
Recommended long-term storage in - 20 ° C, to ensure the longest shelf life of products.
For Research Use Only | Not For Clinical Use
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