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L-Arginine-HCl, 13C6 for SILAC (CAT#: GLJF-0225-HX28)

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Product Description L-Arginine-HCl, 13C6 for SILAC is a specially isotopically labeled form of the essential amino acid L-arginine, supplied as its hydrochloride salt for enhanced solubility and stability. In this compound, all six carbon atoms within the arginine molecule are replaced with the stable isotope carbon-13. This heavy isotope labeling renders the arginine distinguishable from its natural counterpart during mass spectrometry analysis due to the increase in molecular mass.
CAS 201740-91-2
Synonyms 201740-91-2; MFCD00144558; (2S)-2-Amino-5-(diamino(113C)methylideneamino)(1,2,3,4,5-13C5)pentanoic acid;hydrochloride; L-Arginine-13C6 hydrochloride
Formula C6H15ClN4O2
MDL No. MFCD00144558
MW 216.62
InChI InChI=1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1/i1+1,2+1,3+1,4+1,5+1,6+1;
InChI Key KWTQSFXGGICVPE-BJPSCUOKSA-N
Purity Min. 95%
Identity Conforms to structure
Storage Store at 2-8°C for long term storage.
Application L-Arginine-HCl, 13C6 is a stable isotope-labeled form of the essential amino acid L-arginine, where six carbon atoms have been replaced with the heavier isotope 13C. This product is specifically designed for use in stable isotope labeling by amino acids in cell culture (SILAC), a powerful technique in quantitative proteomics. Incorporating this 13C6-labeled arginine into cell culture media allows for the metabolic incorporation of the heavier isotope into all proteins synthesized by the cells. This creates a distinct mass difference compared to proteins from cells grown in standard media, enabling researchers to distinguish and quantify relative protein abundance between different experimental conditions using mass spectrometry. SILAC using this labeled arginine is widely employed to study changes in protein expression, post-translational modifications, and protein-protein interactions in a variety of biological contexts.
For Research Use Only.
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