CD138 Assay Portfolio Service
Introduction What We Can Offer Workflow Why Creative Biolabs Customer Reviews FAQs Related Services Contact Us
Creative Biolabs provides comprehensive solutions for identifying and quantifying CD138 expression, assessing its role in disease progression, and validating its potential as a therapeutic target. Our capabilities span from foundational biomarker characterization to supporting preclinical drug development, ensuring you gain a deeper understanding of CD138's involvement in various cancers. Creative Biolabs provides the expertise and technology to streamline your projects from discovery to preclinical analysis.
Tumor Target CD138
CD138, or Syndecan-1, is a key cell surface proteoglycan prominently expressed on plasma cells, making it a critical biomarker in Multiple Myeloma (MM) and other cancers like breast, pancreatic, and prostate. Its consistent expression on MM cells underpins its utility in diagnosis, prognosis, and minimal residual disease detection. Furthermore, CD138 serves as a promising target for innovative therapies, including antibodies, ADCs, and immunocytokines, which have shown efficacy by modulating survival pathways or acting synergistically with other drugs.
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Fig.1 Overview of CD138 expression in tumorous tissue.1
What We Can Offer
Basic Research & Target Identification
Our advanced CD138 assays, including immunohistochemistry, flow cytometry, and qPCR, are instrumental in the fundamental stages of basic research. We assist in the identification and validation of CD138, precisely confirming its expression patterns and understanding baseline levels across different cell types and tissues.
Discovery: Lead Generation & Characterization
In the drug discovery phase, our services support the development of CD138-targeting leads like antibodies, ADCs, or immunocytokines. We provide robust platforms for high-throughput screening, binding affinity measurements, and functional characterization.
Preclinical Phase: In Vitro & In Vivo Studies
We transition in vitro findings to robust in vivo models for therapeutic efficacy and safety. Our diverse models (PDX, conventional xenograft, and syngeneic) evaluate anti-tumor activities and drug mechanism of action.
Workflow of CD138 Assay Portfolio Service
Highlights
Unmatched Expertise & Proven Track Record
Our team of seasoned scientists provides a deep understanding of complex biological systems. Our meticulous planning and proven history of high-impact results translate to more efficient experimental design and accurate data interpretation.
Cutting-Edge Technology & Rigorous Quality Systems
We invest in state-of-the-art instrumentation, including high-resolution flow cytometers, automated ELISA, and next-generation qPCR systems. We use meticulously validated protocols and adhere to stringent quality control measures, incorporating QbD principles.
Customized Solutions for Every Project
Creative Biolabs excels in providing highly customized CD138 assay services, tailoring experimental designs, assay parameters, and analytical approaches to precisely meet your specific objectives, sample types, and budgetary requirements.
Accelerated Discovery & Actionable Insights
Our streamlined workflows and dedicated project management significantly shorten your project timelines. We deliver comprehensive reports with in-depth analysis and expert interpretation, translating complex results into clear, actionable insights.
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Customer Reviews
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Enhanced Specificity
Creative Biolabs' exceptionally clean flow cytometry data allowed us to confidently distinguish malignant from healthy cells, overcoming a persistent challenge with our in-house methods. This precision has been invaluable. - Dr. J*n, Lead Researcher.
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Reliable Gene Expression
Creative Biolabs' service was instrumental in understanding transcriptional regulation in our drug resistance models. The highly reproducible and consistent data provided a reliable benchmark for our comparative studies, and we especially appreciated the detailed data analysis. - Dr. L*g, Molecular Biologist.
FAQs
Can your service help me differentiate between malignant and healthy plasma cells based on CD138 expression?
Absolutely. Our flow cytometry and Immunohistochemistry services are specifically designed to help distinguish malignant plasma cells, which typically exhibit high and consistent CD138 expression, from other hematopoietic cells.
Are there any specific precautions or considerations for sample handling to ensure optimal results?
Yes, proper sample handling is crucial. We provide detailed guidelines for sample collection, processing, and storage to maintain the integrity of CD138. Factors like anticoagulant choice, temperature control, and timely processing can significantly impact assay quality.
Related Services
Cell Line Characterization
Our services include comprehensive authentication methods such as short tandem repeat (STR) profiling, mycoplasma testing to prevent contamination, and detailed growth curve analysis.
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In Vivo Efficacy
Our diverse models, including PDX, conventional xenograft, and syngeneic, allow for a comprehensive evaluation of key anti-tumor activities like tumor growth, recurrence, and metastasis.
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How to Contact Us
Creative Biolabs' service provides a robust, comprehensive, and expertly delivered solution for all your CD138 analysis needs, from fundamental research to preclinical validation. Leveraging our experience and cutting-edge platforms, we are committed to providing the precise insights necessary to accelerate your projects and contribute to breakthroughs in cancer diagnosis and therapy.
Contact us for more information and to discuss your project.
Reference
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Kind, Simon, et al. "Prevalence of syndecan-1 (CD138) expression in different kinds of human tumors and normal tissues." Disease markers 2019.1 (2019): 4928315. Distributed under an Open Access license CC BY 4.0, without modification. DOI: https://doi.org/10.1155/2019/4928315
For Research Use Only | Not For Clinical Use
