P450-Metric™ Cytochrome P450 2E1 (CYP2E1) ELISA Kit

CAT#: ITS-0326-YL1
Product Type: Assay Kit
Species: Rat, Human, Mouse
Brand: P450-Metric™
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Quantifies CYP2E1 using a double-antibody sandwich ELISA.
Brand
P450-Metric™
Development Stage
ADME
ADME Research Domain
Metabolism
Description
This highly sensitive double-antibody sandwich ELISA kit is expertly engineered for the precise quantitative measurement of Cytochrome P450 2E1 in various biological samples. By delivering exceptional analytical specificity and reproducibility, this research-use-only assay provides scientists with a robust laboratory tool to rigorously evaluate xenobiotic metabolism, predict drug-induced hepatotoxicity, and comprehensively profile early-stage pharmacokinetic pathways in preclinical drug discovery and advanced ADME investigations.
Features
This highly sensitive sandwich ELISA provides precise quantification of CYP2E1, facilitating rigorous in vitro evaluation of drug-induced hepatotoxicity and xenobiotic metabolism for robust ADME profiling.
Process Relevance
Profiling CYP2E1 levels to evaluate solvent metabolism and predict drug-induced hepatotoxicity in preclinical models.
Application Stage
Preclinical drug discovery, ADME profiling, and pharmacokinetic research
Applications
This highly specific sandwich ELISA quantifies target concentrations across tissue homogenates, cell lysates, and biological fluids.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Sample Type
Serum, plasma, tissue homogenates, cell lysates, cell culture supernates
Research Areas
ADME; Drug Metabolism; Pharmacokinetics; Toxicology
Size
48 / 96 tests
Data Output Type
Absorbance (OD)
LOD
Rat: 32 pg/mL
Human: 0.25 ng/mL
Mouse: 1.31 ng/mL
Species
Rat, Human, Mouse
Storage
Upon receipt, please follow the storage recommendations in the USER MANUAL to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. Do not store at elevated temperatures for extended periods.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on ice under temperature-controlled conditions.
Background
Cytochrome P450 2E1 is a crucial hepatic enzyme responsible for the metabolic activation of various low-molecular-weight toxins and pharmaceuticals. In preclinical research, its activity is closely monitored to evaluate xenobiotic-induced oxidative stress and predict potential hepatotoxic liabilities during drug development
For Research Use Only | Not For Clinical Use
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