Short Description
Quantifies GST activity using CDNB substrate.
Development Stage
Research-Grade Protein & Enzyme Assay Development
Description
The ModifiSite™ Glutathione S-transferase Assay Kit utilizes a CDNB conjugation assay to assess phase II detoxification capacity and drug resistance. This assay validates the activity of GSTs, which conjugate xenobiotics to glutathione. It supports research into chemotherapy resistance mechanisms and the toxicology of environmental pollutants.
Features
CDNB conjugation assay; Assessing phase II detoxification capacity and drug resistance.
Process Relevance
ADME/Phase II Detoxification
Application Stage
ADME / DMPK
Applications
Detoxification enzyme and drug resistance research.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Absorbance at 340 nm
Sample Type
Serum, citrate-plasma, urine, cell lysate, culture medium
Research Areas
Drug Metabolism; Oncology
Datasheet