P450-Metric™ Cytochrome P450 2D6 (CYP2D6) ELISA Kit

CAT#: ITS-0326-YL10
Product Type: Assay Kit
Species: Human, Rat
Brand: P450-Metric™
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Quantifies CYP2D6 using a double-antibody sandwich ELISA.
Brand
P450-Metric™
Development Stage
ADME
ADME Research Domain
Metabolism
Description
This reliable double-antibody sandwich ELISA kit is meticulously engineered for the exact quantitative assessment of Cytochrome P450 2D6 across diverse biological matrices. Delivering excellent analytical precision and strict specificity, this research-use-only immunoassay allows scientists to deeply explore critical hepatic biotransformation mechanisms. It is an indispensable tool for profiling the metabolic liabilities of central nervous system therapeutics and evaluating vital systemic drug clearance in ADME studies.
Features
Providing exceptional intra-assay precision, this quantitative ELISA accurately measures CYP2D6, an essential tool for evaluating metabolic clearance and xenobiotic interactions in pharmacokinetic research.
Process Relevance
Measuring CYP2D6 to interpret phenotypic variations in clearance and establish safety margins for basic drugs.
Application Stage
Preclinical drug discovery, ADME profiling, and pharmacokinetic research
Applications
Measure target enzyme expression in cell lysates, tissue homogenates, and complex biological fluids utilizing this precise assay.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Sample Type
Serum, plasma, tissue homogenates, cell lysates
Research Areas
ADME; Pharmacogenomics; Drug Metabolism; Pharmacokinetics
Size
48 / 96 tests
Data Output Type
Absorbance (OD)
LOD
Rat: 0.65 ng/mL
Human: 0.119 ng/mL
Species
Human, Rat
Storage
Upon receipt, please follow the storage recommendations in the USER MANUAL to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. Do not store at elevated temperatures for extended periods.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on ice under temperature-controlled conditions.
Background
Cytochrome P450 2D6 mediates the metabolism of approximately a quarter of common therapeutics, particularly central nervous system and cardiovascular agents. Due to its extensive genetic polymorphism, profiling CYP2D6 activity is critical for predicting systemic clearance rates and characterizing metabolic liabilities.
For Research Use Only | Not For Clinical Use
Online Inquiry