AccuMetab™ Human UGT1A1 Enzyme, Catalytically Active

CAT#: ITS-0426-YL92
Product Type: Recombinant Phase II Metabolizing Enzyme
Brand: AccuMetab
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Human UGT1A1 for precise Phase II glucuronidation ADME screening.
Brand
AccuMetab
Development Stage
ADME
ADME Research Domain
Metabolism
Background
UGT1A1 is the sole human enzyme responsible for bilirubin glucuronidation, and its inhibition by drugs can lead to severe, life-threatening hyperbilirubinemia. Profiling drug candidates against UGT1A1 is a mandatory regulatory requirement to ensure fundamental patient safety and liver function.
Key Features
High-activity Sf9 insect cell microsome format; Mandatory screening target for hyperbilirubinemia risk; Compatible with alamethicin for latency reduction; Requires UDPGA cofactor for assay initiation
Applications
Phase II Drug Metabolism, Glucuronidation Studies
Research Areas
ADME; Phase II Conjugation
Species
Human
Expression System
Recombinant enzymes are prepared from baculovirus-infected Sf9 insect cells.
Physical Form
Liquid
Size
2.5 mg
Storage
-80°C
Storage Comment
When stored at -80°C, our product remains stable and retains full functional activity for up to 10 years.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Our enzyme products are shipped at -80°C.
For Research Use Only | Not For Clinical Use
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