P450-Metric™ Cytochrome P450 46A1 (CYP46A1) ELISA Kit

CAT#: ITS-0326-YL11
Product Type: Assay Kit
Species: Human
Brand: P450-Metric™
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Quantifies CYP46A1 using a double-antibody sandwich ELISA.
Brand
P450-Metric™
Development Stage
ADME
ADME Research Domain
Metabolism
Description
This specialized double-antibody sandwich ELISA kit provides highly accurate quantitative measurement of Cytochrome P450 46A1 within central nervous system tissue homogenates and lysates. Exhibiting superior sensitivity and zero cross-reactivity, this research-use-only product helps investigators elucidate brain-specific cholesterol turnover and specialized lipid-drug metabolism. It operates as a critical analytical foundation for studying the neuro-pharmacokinetics of lipophilic xenobiotics in rigorous preclinical ADME and drug development investigations.
Features
This quantitative double-antibody ELISA ensures highly specific measurement of CYP46A1, empowering ADME researchers to deeply investigate brain-specific cholesterol turnover and specialized lipid-drug metabolism.
Process Relevance
Quantifying CYP46A1 to evaluate local central nervous system pharmacokinetics and brain sterol metabolism interactions.
Application Stage
Preclinical drug discovery, ADME profiling, and pharmacokinetic research
Applications
Employ this quantitative sandwich ELISA to accurately measure target concentrations in tissue homogenates and relevant biological fluids.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Sample Type
Serum, plasma, tissue homogenates, cell lysates
Research Areas
ADME; Neuropharmacology; Drug Metabolism; Pharmacokinetics
Size
48 / 96 tests
Data Output Type
Absorbance (OD)
LOD
Human: 0.27 ng/mL
Species
Human
Storage
Upon receipt, please follow the storage recommendations in the USER MANUAL to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. Do not store at elevated temperatures for extended periods.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on ice under temperature-controlled conditions.
Background
Exclusively expressed in the central nervous system, Cytochrome P450 46A1 drives the conversion of cholesterol to 24S-hydroxycholesterol for cerebral lipid clearance. ADME researchers analyze its activity to establish the neuro-pharmacokinetic profiles of highly lipophilic xenobiotics and targeted neurotherapeutics.
For Research Use Only | Not For Clinical Use
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