Cellular therapy is to inject cellular materials into a patient for therapeutic purpose. Gene therapy is to manipulate or modify the expression of a gene or alter the biological properties of cells for therapeutic purpose. Creative Biolabs is dedicated to establishing the most appropriate animal models for the development of your CAR-T products including pharmacology services and toxicology services.
Creative Biolabs is dedicated to a full spectrum of preclinical services for cellular and gene therapy (CGT) products including oncolytic virus, plasmid DNA, viral vectors, bacterial vectors, human gene editing technology, patient-derived cellular gene therapy products, and stem cell derived cells, mature/functionally differentiated cells, such as T cells, NK cells and macrophage cells.
Careful selection of animal models is critical for proof-of-concept studies and pharmacologically sensitive species for CGT products that offered to anticipated clinical route of administration. For animal models with competent immune system, we can inhibit immune response via immunosuppressive agents to ensure cell survival after implantation. In addition, we offer surgically altered models as per specific requirements. Our various surgical implantation methods include intraocular, intraspinal, intracranial, intrathecal, myocardial, intracoronary, topical grafting, intraprostatic, infusion, and they can mimic clinical routes of administration which is important for program success. For detailed animal model types, please visit the following modules.
Immunological toleranceFor animal models with competent immune system, if the animal model rejects the product, we can provide different strategies to inhibit immune response to ensure cell survival after implantation.
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Animal model species
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Routes of administration
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Here are some specific considerations for animal models in the development of cellular and gene therapy products. If you are interested in any part, please contact us for a deep communication to learn how we can be involved in your project.
With high quality commercial breeding facilities, genetic standards and rigorous biosecurity, and relative research support services, Creative Biolabs is dedicated to providing you with specific animal models to fit your CGT product discovery and development. Please contact us for detailed information and deep communication about your program.
For Research Use Only | Not For Clinical Use