PharmaOnco™ GAD65-Specific T cells

CAT#: ITS-0423-LX5
Product Type: OncoImmune Cells
Cell Type: T cell population
Species: Human
Short Description
Creative Biolabs offers GAD65-Specific T cells for immunity reaserch.
Description
GAD65-specific T cells are T cells that are specific for the enzyme glutamic acid decarboxylase 65 (GAD65), which is found in the pancreas and is thought to play a role in the development of type 1 diabetes. These T cells recognize and target GAD65 as an antigen, leading to an autoimmune response that can lead to the destruction of insulin-producing beta cells in the pancreas. This ultimately results in the development of type 1 diabetes.
Background
GAD65-specific T cells are a type of T cell that specifically targets the glutamic acid decarboxylase 65 (GAD65) protein. GAD65 is an enzyme involved in the synthesis of the neurotransmitter gamma-aminobutyric acid (GABA) and is a major autoantigen in type 1 diabetes. GAD65-specific T cells play a critical role in the pathogenesis of type 1 diabetes by recognizing and attacking beta cells in the pancreas that produce insulin. When activated, these T cells can induce inflammation and destruction of pancreatic beta cells, leading to a loss of insulin production and the development of diabetes.
Species
Human
Cell Type
T cell population
Culture medium
We recommend RPMI-1640 with 10% FBS media for our functional analysis, but that depends on the media used by customers for co-culturing experiments.
Features
High quality;
High viability;
Widely applications.
Survive Time
With proper stimulation, they will survive for about 4-5 days.
Antigen
GAD65 (555-567)
Gender
Male
Donor Age
50
Donor Health
Normal
HLA-A
24:07:00
HLA-B
35:05:00
HLA-C
4:01:00
Blood Type
B+
Ethnicity
Hispanic
Anticoagulant
Acid-citrate-dextrose solution A (ACDA)
Additional Donor Information
Contact us for donor specifications (Age,Gender,BMI category, smoking status, ethnicity, etc.).
Formulation
Contains Cryopreservation Medium
Cell Purity
>80%
Cell Viability
>80%
Mycoplasma Testing
Negative
Sterility Testing
Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.
Genetic Stability Testing
We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.
Application
Immunotherapy Discovery and Development
Quality Control
Cultures are screened for the presence of bacteries, yeast, fungi and mycoplasma (DNA amplification). Growth media are also certified based on U.S. Public Health Service Guidelines.
Storage
Frozen cells should be stored in a liquid nitrogen tank (-150°C~-194°C).
Handling Notes
Frozen cells should be thawed according to handling procedure or stored in a liquid nitrogen tank.
Warnings
Avoid multiple freeze/thaw cycles.
Size
1 x 10e6 cells/vial
Status
Frozen
Note
Certain products are only available in select territories. Please contact us for more information.
For Research Use Only | Not For Clinical Use
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