Creative Biolabs offers Human CD14+ Monocytes for immunity reaserch.
Description
Human CD14+ monocytes are a type of white blood cell that plays a key role in the immune system. They express the cell surface marker CD14, which is a receptor for lipopolysaccharide (LPS) and other microbial molecules, allowing them to recognize and respond to pathogens. CD14+ monocytes circulate in the bloodstream and can differentiate into macrophages or dendritic cells upon activation. They play a crucial role in the innate immune response by phagocytosing pathogens, producing inflammatory cytokines, and activating other immune cells. Abnormalities in CD14+ monocytes have been associated with various diseases, including sepsis, autoimmune disorders, and cancer.
Background
Monocytes are a type of white blood cell (leukocytes) that reside in your blood and tissues to find and destroy germs (viruses, bacteria, fungi and protozoa) and eliminate infected cells. They are produced in the bone marrow and then enter the blood, where they account for about 1 to 10% of the circulating white blood cells. They are the largest type of leukocyte and can differentiate into macrophages and conventional dendritic cells.
Species
Human
Cell Type
Monocytes
Source
Peripheral Blood
Features
High quality; High viability; Widely applications.
Donor Health
Normal
Anticoagulant
Acid-citrate-dextrose solution A (ACDA)
Additional Donor Information
Contact us for donor specifications (Age,Gender,BMI category, smoking status, ethnicity, etc.).
Formulation
Contains Cryopreservation Medium
Cell Purity
> 90% CD14+ by flow cytometry
Mycoplasma Testing
Negative
Sterility Testing
Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.
Genetic Stability Testing
We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.
Application
Immunotherapy Discovery and Development
Research Use Only
Our products are for research use only, not for diagnostic or therapeutic use.
Quality Control
Donors are screened for HIV-1, HIV-2, hepatitis B, and hepatitis C.
Storage
Store at -135°C or colder for 12 months from date of receipt.
Handling Notes
When handling biohazardous materials such as human cells, safe laboratory procedures should be followed and protective clothing should be worn.
Warnings
Creative Biolabs cannot guarantee the biological function or any other properties associated with performance of this product in a researcher's individual assay or culture systems.
Size
1 x 10e6 cells/vial
Status
Frozen
Note
Certain products are only available in select territories. Please contact us for more information.