PharmaOnco™ Human Central Memory CD8+ T Cells

CAT#: ITS-0622-YT542
Product Type: Primary human cells
Cell Type: Central memory CD8+ T cells
Species: Human
Short Description
Creative Biolabs offers Human Central Memory CD8+ T Cells for immunity reaserch.
Description
Central memory CD8+ T cells are a subset of memory T cells that are located in secondary lymphoid organs, such as lymph nodes and spleen. These cells are characterized by their longevity and ability to rapidly respond to re-infection with the same antigen. They express high levels of the lymph node homing receptor CD62L and the chemokine receptor CCR7, which allows them to home to lymphoid tissues where they can quickly mount an immune response.
Background
Memory CD8+ T cells were originally thought to exist as two populations (effector and central memory). Central memory CD8+ T cells, which express the secondary lymphoid organ-homing molecules CCR7 and CD62L, are mainly found within the spleen and lymph nodes, lack immediate effector function and have increased ability to generate secondary immune responses. It control systemic secondary infections and can protect from chronic infection and cancer as a result of their stem-cell-like capacity to expand, differentiate, and self-renew.
Species
Human
Cell Type
Central memory CD8+ T cells
Source
Peripheral Blood
Features
High quality;
High viability;
Widely applications.
Donor Health
Normal
Anticoagulant
Acid-citrate-dextrose solution A (ACDA)
Additional Donor Information
Contact us for donor specifications (Age,Gender,BMI category, smoking status, ethnicity, etc.).
Formulation
Contains Cryopreservation Medium
Cell Purity
>90% CD3+CD8+CD45RO+ by flow cytometry immediately after isolation,> 80% CD62L+CD45RO+ (as a percentage of CD8+CD3+ cells) by flow cytometry after 24 hours in culture
Mycoplasma Testing
Negative
Sterility Testing
Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.
Genetic Stability Testing
We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.
Application
Immunotherapy Discovery and Development
Research Use Only
Our products are for research use only, not for diagnostic or therapeutic use.
Quality Control
Donors are screened for HIV-1, HIV-2, hepatitis B, and hepatitis C.
Storage
Store at -135°C or colder for 12 months from date of receipt.
Handling Notes
When handling biohazardous materials such as human cells, safe laboratory procedures should be followed and protective clothing should be worn.
Warnings
Creative Biolabs cannot guarantee the biological function or any other properties associated with performance of this product in a researcher's individual assay or culture systems.
Size
1 x 10e6 cells/vial
Status
Frozen
Note
Certain products are only available in select territories. Please contact us for more information.
For Research Use Only | Not For Clinical Use
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