PharmaOnco™ Human M1 Macrophages

CAT#: ITS-0622-YT581
Product Type: Primary human cells
Cell Type: Macrophages
Species: Human
Short Description
Creative Biolabs offers Human M1 Macrophages for immunity reaserch.
Description
M1 macrophages are a type of immune cell that play a key role in the inflammatory response. They are classically activated by signals such as interferon-gamma or lipopolysaccharide, leading to the production of pro-inflammatory cytokines and the promotion of inflammation. M1 macrophages are also involved in phagocytosis of pathogens and infected cells, helping to clear the body of harmful invaders.
Background
Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal tissue development, homeostasis, and repair of damaged tissue. Macrophages are classified into pro-inflammatory (M1), non-activated (M0) or anti-inflammatory (M2) subsets that play distinct roles in the initiation and resolution of inflammation.
Species
Human
Cell Type
Macrophages
Source
Peripheral Blood
Features
High quality;
High viability;
Widely applications.
Donor Health
Normal
Anticoagulant
Acid-citrate-dextrose solution A (ACDA)
Additional Donor Information
Contact us for donor specifications (Age,Gender,BMI category, smoking status, ethnicity, etc.).
Formulation
Contains Cryopreservation Medium
Cell Purity
> 90% CD80+,> 50% CCR7+, ≤ 10% CD206+, and ≤ 10% CD209+ by flow cytometry
Mycoplasma Testing
Negative
Sterility Testing
Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.
Genetic Stability Testing
We perform cell genetic stability studies under ICH guidelines. We can provide guidance on the appropriate testing program upon your requirements.
Application
Immunotherapy Discovery and Development
Research Use Only
Our products are for research use only, not for diagnostic or therapeutic use.
Quality Control
Donors are screened for HIV-1, HIV-2, hepatitis B, and hepatitis C.
Storage
Store at -135°C or colder for 12 months from date of receipt.
Handling Notes
When handling biohazardous materials such as human cells, safe laboratory procedures should be followed and protective clothing should be worn.
Warnings
Creative Biolabs cannot guarantee the biological function or any other properties associated with performance of this product in a researcher's individual assay or culture systems.
Size
1 x 10e6 cells/vial
Status
Frozen
Note
Certain products are only available in select territories. Please contact us for more information.
For Research Use Only | Not For Clinical Use
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