PathSpecific™ SRC Cell-based Phosphorylation Assay (CAT#: ZL-1122-LX339)
| Overview | |
|---|---|
| Short Name | SRC Cell-based Phosphorylation Assay |
| Assay Overview | Creative Biolabs provides several specific target assays for the investigation of test articles focus the specific pathway. This assay is applied for compound screening and profiling in intact cells and will be customized according to the client's specific requirements. Please contact our scientists for assay development and custom-tailored screening details. |
| Assay type | Phosphorylation Assay |
| Assay Properties | |
|---|---|
| Short Description | For compound screening and profiling in intact cells |
| Substrates/Cell Line | Mouse Embryonic Fibroblasts (MEF) |
| Target Expression | Transfected |
| Assay subtype | Cell-based Phosphorylation Assay |
| Assay format | 96-wells format |
| Target | |
|---|---|
| Target | SRC |
| Synonyms | ASV; SRC1; c-SRC; p60-Src |
| Target Species | Human |
| Target Description | SRC is a 60 kDa protein consisting of several domains which mediate its diverse functions. The cytosolic SRC protein-tyrosine kinase is a regulatory protein that plays a key role in cell differentiation, motility, proliferation and survival. Activated Src is common in human tumors. Human SRC is rarely mutated into an oncogene but is rather dysregulated via overexpression, reduced degradation or mRNA stability. SRC activity has an important oncogenic role transmitting signals from other oncogenes such as EGFR, HER2, and PDGFR. In this context SRC is considered to promote the metastatic phenotype. |
For Research Use Only.
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