Cardiovascular Toxicity

As a leading CRO in the world, Creative Biolabs has the ability to provide you the latest technologies along with our experience in the study of cardiovascular toxicity. In combination with years of experience and our seasoned team of experts, we guarantee our global clients the most reliable service at the most competitive price. Our all-around animal study services will greatly promote our client's IND-enabling process.

Introduction of Cardiovascular Toxicity

Human heart is a frequent site of toxicity caused by pharmaceutical compounds. Among all the main aspects of cardiovascular diseases (CVDs), heart failure has been the most common causes of death. Also, the treatment of these diseases generates an enormous cost for the healthcare system. Furthermore, adverse cardiac side effects have led the most common cause of drug withdrawal from the market and delays in regulatory approval for marketing. Therefore, it is critical to evaluate the possible adverse effects on cardiac structure and function of new drug candidates.

Fig.1 A working model by which doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes. (Zhao L, 2017)

Cardiovascular Toxicity Provided by Creative Biolabs

Has conducted cardiovascular toxicity studies for several years, Creative Biolabs is capable of offering a variety of in vivo, in vitro, and ex vivo testing methods for our clients all over the world, which including but not limited to:

• In vivo cardiac models - we can provide both rodents and non-rodent in vivo cardiac models for your investigation. The species include rat, mice, rabbit, dogs, monkeys, swine, ferrets, guinea pigs and so on.
• Ex vivo models - to meet the specific requirement of clients, we also offer the explanted hearts and cardiac tissue service.
• In vitro test methods
  3D cardiotoxicity assay
  hERG safety assay
  QT prolongation assay
  Arrhythmogenic liability screening
  Comprehensive in vitro proarrhythmia assay (CiPA) - a high-throughput assay that assesses drug effects on each cardiac ion channel type individually.

Including cardiovascular toxicity service, we provide a comprehensive pipeline of toxicology study services to meet every client's requirements. If you are interested in the service we can provide, please click the links below.

Creative Biolabs is committed to providing high-quality and cost-effective service for our clients. With years of experience, our professional scientists will work closely with you to make your project a success. For more detailed information, please feel free to contact us or directly sent us an inquiry.

Reference

1. Zhao L, Zhang B. Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes [J]. Scientific reports, 2017, 7: 44735.

For Research Use Only.