Creative Biolabs has established an incomparable web-based immunogenicity screening platform. With our experienced scientists, our team can provide high-quality immunogenicity analysis services to help global customers find potential factors that lead to immunogenicity.
Introduction of Web-based Immunogenicity Screening
During the past years, the unwanted immunogenicity of biological drugs has greatly hampered the development of new therapies into the market, as it possibly compromises drug safety and alters pharmacokinetics. Studies have shown that the immunogenicity of therapeutic protein is driven by both external and intrinsic factors. Among the external factors are dosage, frequency, mode of administration, purity, formulation of the product, genetic background, concomitant use of immunosuppressive drugs, and the disease state of the patient. On the other hand, B and T cell epitopes are an intrinsic part of the therapeutic protein and their presence is essential for the development of antibody responses. Web-based immunogenicity screening is an in silico method that was established to identify potential cell epitopes of virtually all human leukocyte antigen molecules from a wide genetic background.
Fig.1 Dendritic cells and CD4+ T-cells - initiators of the immunogenic cascade leading to formation of anti-drug antibodies by B cells. (Kropshofer, 2006)
Web-based Immunogenicity Screening Services Provided by Creative Biolabs
With advanced technology and professional scientists, Creative Biolabs has successfully established a web-based immunogenicity screening platform for high-throughput screening of partial and complete sequences of biological drugs even in the very early development cycle, such as lead selection. Based on the cutting-edge technology platform, we can help our clients identify potentially immunogenic regions within each protein sequence. Especially, the services we can provide include:
Features of Our Services
Aided by advanced web-based immunogenicity screening platform, Creative Biolabs is able to help worldwide customers identify cell epitopes from a wide genetic background. The services we provide will be presented in a relatively inexpensive manner. In addition to web-based immunogenicity screening service, we also provide other immunogenicity assessment services for global customers. We are confident to promote your project a success. If you are interested in the services we provide, please feel free to contact us for more information.
Reference
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