Creative Biolabs is engaged in providing highly reliable and cost-effective skin irritation testing services for our worldwide customers. Having worked in the field of preclinical safety assessment for many years, we have established unparalleled platforms with advanced technology to accelerate our client's programs development. We warmly welcome our customers to consult and negotiate their cutting-edge projects with us.
Introduction of Skin Irritation
According to the definition by the Globally Harmonized System of Classification and Labeling of Chemicals (GHS), skin irritation is referred to “the production of reversible damage to the skin following the application of a test substance for up to 4 hours”. Many kinds of products can lead to skin irritation by passing through the stratum corneum and enter the layers beneath which typically characterized by redness, itching or pain in the area of contact with the product. Therefore, it is an important part of skin irritation test in preclinical safety evaluation.
Skin Irritation Test
During the past years, numerous test approaches for skin irritation testing have been developed including the conventional in vivo animal test (Draize rabbit test) and in vitro test methods. For a long time, the Draize rabbit skin irritation test has been a gold standard test since it was developed in 1944. But it was later proved that animal studies are highly variable, of limited reliability, and generally poor predictors of human skin reactions. Fortunately, several alternative in vitro testing methods are available to replace of animal-based skin irritation tests. Furthermore, all of these accepted methods are validated by ECVAM and based on the reconstructed human epidermis (RHE) technology which has already been accepted by many agencies.
Fig.1 Images of skin irritancy study: (a) patch application to shaved area; (b) skin of rabbit at 0 day; (c) skin of test group rabbit after 7 days of patch application; (d) skin of standard group rabbit after 7 days. (Panchaxari D M, et al. 2013)
Skin Irritation Test Provided by Creative Biolabs
As a leading CRO company with abundant experience in the world, Creative Biolabs can provide both animal-based and animal-free skin irritation tests for our global customers, which including but not limited to:
You may also be interested in other local toxicity studies:
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Including skin irritation test, we provide comprehensive and customized toxicology studies to meet every client's requirements. If you are interested in the services we can provide, please click the links below.
Creative Biolabs will be your trusted partner in every step in your new drug investigation. For more detailed information and get a quote, please feel free to contact us.
Reference
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