Musculoskeletal Toxicity

As a leading CRO in the world, Creative Biolabs is capable of providing a series of preclinical musculoskeletal toxicity services for our worldwide customers. With years of experience and advanced technology, our professional scientists can provide you the safety and efficacy information of your test articles and devices that probably have an intentional or unintentional effect on the musculoskeletal system.

Importance of Musculoskeletal Toxicity Assessment

Musculoskeletal Toxicity is the adverse effects to the structure and/or function of the muscles, bones, and joints caused by drugs or chemicals. Unfortunately, it may lead to severe health problems such as arthritis, fluorosis, and osteomalacia. It is often chronic and progressive, leading to deformities and disability. Studies have suggested that numerous drugs have the potential to induce musculoskeletal toxicity. Therefore, it is an essential part of musculoskeletal toxicity assessment in preclinical drug investigation.

Musculoskeletal Toxicity Services Provided by Creative Biolabs

Whether you are trying to evaluate potential musculoskeletal toxicity during lead optimization or to verify in vivo efficacy, Creative Biolabs can provide a number of relevant musculoskeletal disease models to overall evaluate the intentional or unintentional effect of your drug candidates on the musculoskeletal system. Our experienced scientists will work closely with you to accelerate the development of your programs. The services available at Creative Biolabs include:

• Gonadectomy (ovariectomy and orchiectomy)-induced bone loss for osteoporosis drug testing
• Bone defect models
• Schenk model in weanling rats (screen for anti-resorptive agents)
• Rheumatoid arthritis models
• TPTx (thyroparathyroidectomy) model
• Osteoarthritis models
• 5/6 nephrectomy model
• Orthopedic models

Advantages of Our Services

• Comprehensive support services available
• Biochemical markers of bone and cartilage turnover
• Micro-CT scanning
• Imaging using bone densitometry techniques
• Radiographic diagnostics (X-ray)
• Histomorphometry and histology
• Biomechanical strength testing

• Standard and personalized program design
• Professional experts with extensive knowledge and experience
• Companion services: computerized environmental control and monitoring system

Creative Biolabs is dedicated to providing the most high-quality and cost-effective services to promote our client's IND-enabling process development. Including musculoskeletal toxicity study, we provide comprehensive toxicology services for our worldwide customers. To learn more details about the services we can provide, please click the links below.

We are happy to help every step of your drug investigation process. For more detailed information, please feel free to contact us or directly sent us an inquiry.

For Research Use Only.