With extensive experience and world-class technologies, Creative Biolabs is capable of providing a full range of liver toxicity assessment services for our clients all over the world. Aiming at offering the most high-quality and cost-effective services, we have established advanced preclinical experiment platform which enables us conducting numerous toxicology assays under both GLP and non-GLP conditions.

Importance of Liver Toxicity Assessment

As a vital role in transforming and clearing chemicals in the human body, the liver is also a frequent target tissue of toxicity from all classes of toxicants as the structure and function predispose it to high sensitivity to xenobiotics. Certain medicinal agents as well as chemical agents, when taken in overdoses or sometimes within therapeutic dose range, may induce the liver cell injury. Importantly, it has been reported that more than 900 drugs can result in liver injury. In addition, Drug-Induced Liver Injury (DILI) has been one of the major causes of approved drug withdrawal post-market. Therefore, it is crucial to identify the potential hepatotoxicity of chemical substances at an early stage in the IND-enabling development process.

Liver Toxicity Services Provided by Creative Biolabs

As a leading CRO in the world, Creative Biolabs has developed a multiplexed hepatotoxicity assays for our global clients. With abundant experience and advanced technology, our professional scientists are capable of offering in vitro cell-based toxicity assays to imitate in vivo tissue studies for safety evaluation in early stages of drug discovery. The liver toxicity evaluation services available at Creative Biolabs currently including but not limited to:

  • In silico models
    • QSAR/Molecular descriptors
    • Structural alert
  • 2D in vitro cell models
    • HepG2
    • Co-cultured with human hepatocytes, stromal cells
    • In vitro cell-free assays
  • 3D liver toxicity model
    • 14 Day Hepatotoxicity Testing
    • Cross-species Hepatotoxicity Testing
    • DILI Evaluation Service
  • Acute liver failure
  • CYP assay

Features of Our Services

  • Fully customizable experimental design to expand beyond standard testing result
  • Through consultation and reporting from proposal to project completion
  • Rapid turnaround with advanced technology
  • Competitive price with the best quality

In recent years, Creative Biolabs has successfully finished a large amount preclinical toxicology study services for our customers all over the world. We are proud to design and perform the unique protocol to provide the high-quality services to meet our client's specific requirements. Including liver toxicity, we provide various toxicology evaluation service for our global clients. If you are interested in our service, please click the links below.

Creative Biolabs is committed to providing our clients with one-stop service through our in-house analytical support in a quick and cost-effective way. For more detailed information, please feel free to contact us or directly sent us an inquiry.

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