As a leading CRO with extensive experience in the world, Creative Biolabs is capable of offering a wide range of preclinical toxicology services for our global customers, which including but not limited to inhalation toxicology service. Our scientists and specialists are more than happy to help our clients accelerate their IND-enabling process development.

Introduction of Inhalation Toxicity Evaluation

Inhalation toxicity refers to the adverse effects that caused by unintended exposure to contaminants or chemicals, which range from simple irritation to morbidity. It is one of the major contributors to human lung or airway health problems. According to the requirements of EPA and FDA, inhalation toxicity study should be conducted before clinical trials to determine whether drug candidates have the potential ability to induce inhalation toxicity, including industrial compounds, pharmaceuticals, biological and chemical materials.

Inhalation Toxicity Available at Creative Biolabs

Determining inhalation toxicity is more difficult and requires special equipment that allows quantitative dosing of chemicals. With advanced technology and experienced scientists, Creative Biolabs has the ability to provide a series of inhalation toxicity services, including:

  • Acute to chronic toxicity through to carcinogenicity
  • Anti-asthmatic efficacy
  • Neonatal inhalation
  • Whole body, nose-only, oronasal, and head-only exposure
  • Intranasal
  • Intratracheal
  • Oropharyngeal
  • Reproductive inhalation
  • Immunologic sensitization via inhalation
  • Radiolabeled aerosol studies

Inhalation ToxicityFig.1 Mechanism outlining the major responses initiated by asbestos-fibre exposure in lung tissue. (Marbbn C.2009)

In addition, various commercially available and in-house designed generation systems and professional experts enable us to conduct all of the studies for a wide range of chemicals and drugs with complex properties, such as:

  • Gas or vapors
  • Liquids and suspensions
  • Powders, fibers or nanoparticles
  • Electronic cigarettes or tobacco product smoke
  • Metered dose inhaler formulations and devices

Advantages of Our Services

  • Extensive knowledge and vast experience in aerosol science and inhalation exposure
    Our team includes aerosol experts who can provide the support to meet your requirement.
  • State-of-the-art generation systems to perform studies
    Our laboratories are well equipped with multi-port inhalation chambers and monitoring systems to conduct various types of inhalation exposures.
  • Various complex test substance can be studied
    Our toxicologists are experienced with complex test samples, such as powders, fibers, nanoparticles, and nanofibers.
  • Personalized program design to meet your specific needs including non-standard and customized studies

Creative Biolabs is dedicated to providing one-stop service for worldwide customers. Including inhalation toxicity service, we provide a comprehensive service of toxicology studies following as below. For more detailed information, please click the links below.

We are happy to be your reliable partner in the IND-enabling development process. If you are interested in the service we provide, please don't hesitate to contact us or get a quote.

Reference

  1. Marbbn C. Asbestos Risk Assessment [J]. The Journal of Undergraduate Biological, 2009.

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