Immunotoxicity

After years of efforts and experience, Creative Biolabs has successfully established a world-leading preclinical experiment platform. We are now providing one-stop preclinical service for our global customers to facilitate their cutting-edge programs best. Particularly, our professional scientists enable us providing a comprehensive package of immunotoxicity study services to identify a compound's potential to be an immunosuppressor or an immunostimulator.

Introduction of Immunotoxicity

The human immune system encompasses a series of cells and organs that can be adversely affected by drugs or chemicals. Changes in immunity may signify adverse toxic side effects including suppression or enhancement of the immune response. In addition, immunosuppression or enhancement can be associated with two distinct groups:

• Drugs intended to modulate immune function for therapeutic purposes (e.g. to prevent organ transplant rejection) where adverse immunosuppression can be considered exaggerated pharmacodynamics.
• Drugs not intended to affect immune function but cause immunotoxicity due, for instance, to necrosis or apoptosis of immune cells or interaction with cellular receptors shared by both target tissues and non-target immune system cells.

Therefore, it is crucial to evaluate the potential adverse effects on the immune system of new drugs before clinical trials, especially for biotechnology products.

Immunotoxicity Studies Provided by Creative Biolabs

As the EMA guidelines require, all new medical products should be tested for their potential immunotoxic. Over the past years, Creative Biolabs has investigated the immunotoxicity of hundreds of candidate drugs for our customers. Our experienced team of specialized scientists enables us not only to advise on study design but also to offer a wide range of in vitro and in vivo immunotoxicology assays following as below:

• In Vivo Evaluation of Immune Response
• Protein toxicokinetics
• Anti-drug antibody monitoring
• Immunogenicity testing
• Developmental immunotoxicity testing
• Host resistance assays
• Innate Immunity
• Hypersensitivity testing
• Inflammation and asthma models
• Natural Killer Cell Activity Assays

• In Vitro Evaluation of Immune Response (Molecular Immunology)
• T-Cell dependent antibody responses (TDAR)
• Flow cytometry
• Immunohistochemistry
• Cytokine quantitation
• Functional assays (T-Cell, B-Cell, Macrophage, Neutrophil)
• Immune response analysis
• ELISA
• Neutralizing antibody and other cell-based assays
• Molecular biology assays

Creative Biolabs aims to get the highest quality results for our customer's research. Including immunotoxicity studies, we also provide other toxicology study services following as below. For more detailed information, please feel free to contact us or directly sent us an inquiry.

For Research Use Only.