As a leading CRO in the world, Creative Biolabs has gained abundant experience in providing a full range of qualified safety studies to detect the most commonly observed adverse events in gastrointestinal tract functions. With advanced technology and professional scientists, we are confident in accelerating our customer's drug development process by delivering the most high-quality and cost-effective preclinical toxicology service.

Importance of Gastrointestinal Toxicity

The gastrointestinal tract, which forms a barrier against unwanted materials and acts as a major site of biotransformation and excretion, is critical for normal body homeostasis with the function of digesting and absorbing nutrients. Studies have shown that many drugs can cause gastrointestinal toxicity, such as gastrointestinal injury, gastrointestinal perforation, gastrointestinal bleeding and so on. Therefore, it is essential to determine the potential gastrointestinal toxicity of the drug candidate before clinical trials.

Gastrointestinal Toxicity Service Provided by Creative Biolabs

Gastrointestinal toxicities, particularly in the stomach, small intestine and colon, are not easy to measure. This is partly due to the complex nature of tissue comprising the alimentary tract and functional alterations of these components in response to a toxic insult. With years of experience in preclinical toxicology study, Creative Biolabs has the ability to provide a comprehensive service of both in vivo and in vitro test methods to promote our client's drug investigation process, which including but not limited to:

  • In vivo models
    • Gastric acid secretion and ulcers
    • Mucosal irritation
    • Gastrointestinal motility
    • Inflammatory bowel disease (IBD)
    • Irritable bowel syndrome (IBS)
    • Emesis, including 5-HT emetic models
  • In vitro models
    • Enzymatic digestion model
    • Colon model
    • Mouth model
    • Hydrolysis index model
    • Particle size model
    • In vitro cytotoxicity
  • 3D Intestinal Organoid Model

Creative Biolabs is committed to providing both standard and specific preclinical services for our worldwide customers. Including gastrointestinal toxicity service, we offer various toxicology services to meet every client's requirements. For more information, please click the links below.

With exceptional team and proven technology, Creative Biolabs will be the right choice to deliver comprehensive preclinical safety evaluation profiles and decision-making guides focusing on IND-enabling process. We can formulate customized plans and conduct tailored protocols with different endpoints and parameters to address specific demands from clients. For more detailed information, please feel free to contact us and get a quote. We will get in touch with you timely.

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